Sökning: "peroxisome"

Visar resultat 16 - 20 av 67 avhandlingar innehållade ordet peroxisome.

  1. 16. Immunohepatotoxicity of the persistent environmental pollutants perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS)

    Författare :Mousumi Rahman Qazi; Joe DePierre; Christopher Lau; Stockholms universitet; []
    Nyckelord :Perfluorooctanoate; Perfluorooctane sulfonate; Peroxisome proliferator-activated receptor-alpha; Hepatomegaly; Immunotoxicity; Thymus; Spleen; Biochemistry; biokemi;

    Sammanfattning : Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS), manufactured for a variety of industrial and consumer applications, are ubiquitous environmental pollutants. Their accumulation in humans and wildlife raises serious health concerns. Here, we examined the potential effects of PFOA and PFOS on the innate immune system in mice. LÄS MER

  3. 17. Congenital Recessive Ichthyosis : Studies of Gene Expressions Related to Keratinocyte Differentiation and Skin Barrier Repair

    Författare :Hanqian Zhang; Hans Törmä; Anders Vahlquist; Marie Virtanen; Mikael Ivarsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genodermatoses; oligoarray; trancriptomics; transglutaminase-1; cornified envelope; peroxisome proliferator-activated receptor δ; all-trans retinoic acids.; Dermatologi och venereologi; Dermatology and Venerology;

    Sammanfattning : Autosomal recessive congenital ichthyosis (ARCI) is a rare monogenetic disorder characterized by a defective skin barrier, hyperkeratosis, and dry, scaly skin. It affects keratinocyte differentiation and is caused by mutations in any of at least 12 genes believed to control the formation of ω-O-acylceramide and the corneocyte lipid envelope (CLE): ABCA12, ALOXE3, ALOX12B, CERS3, CYP4F22, ELOVL4, LIPN, NIPAL4, PNPLA1, SDR9C7, SLC27A4, and TGM1. LÄS MER

  4. 18. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

    Författare :Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

    Sammanfattning : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. LÄS MER

  5. 19. Molecular cloning and characterization of the murine acyl-CoA thioesterase CTE-I

    Författare :Per J G Lindquist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acyl-CoA thioesterase; acyl-CoA; peroxisome proliferator-activated receptor alpha; fatty acid metabolism;

    Sammanfattning : Mouse cytosolic type I acyl-CoA thioesterase (CTE-I) is a member of the type I family of acylCoA thioesterases. These enzymes hydrolyze acyl-CoAs to non-esterified fatty acids (NEFAs) and Coenzyme A (CoA-SH) and are strongly induced in rodent liver by a diverse group of compounds called peroxisome proliferators. LÄS MER

  7. 20. PPAR delta : its role in cholesterol metabolism

    Författare :Josefin Skogsberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Peroxisome proliferator activated receptor delta; polymorphism; association studies; LDL-cholesterol; coronary heart disease; LDL receptor; gene expression;

    Sammanfattning : Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors that regulate several biological processes, many of which are crucial for energy homeostasis. Three different isotypes have been identified; PPARalpha, PPARdelta and PPARgamma that are encoded by different genes and show different expression patterns and functions. LÄS MER