Sökning: "periostin"

Hittade 5 avhandlingar innehållade ordet periostin.

  1. 1. Inflammation in asthma: relation to symptomatology, exacerbations and lung function

    Författare :Ida Mogensen; Andrei Malinovschi; Christer Jansson; Mona Bafadhel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; eosinophil; eosinophil cationic protein; eosinophil derived neurotoxin; periostin; neutrophil; fixed airflow obstruction; lung function; asthma attack; asthma symptom;

    Sammanfattning : Asthma is an inflammatory disease in the airways. It is characterized by respiratory symptoms such as wheezing, variable airflow obstruction and impaired lung function development. A better understanding of the underlying inflammation is crucial in order to treat and prevent asthma symptoms and lung function deterioration. LÄS MER

  3. 2. Tissue remodelling in pulmonary fibrosis linked to 5-HT2 receptor activation

    Författare :Anna Löfdahl; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Serotonin 5HT ; Serotonin class 2 receptor antagonist; Fibroblast; Pulmonary fibrosis; Extracellular matrix ECM ;

    Sammanfattning : After an injury, an immediate reparative response is triggered to replace the damaged tissue, however, in fibrosis, cells remain active despite wound resolution causing a steady build-up of fibrotic tissue. In pulmonary fibrosis,there is a constant regeneration and remodelling of lung tissue where the thin architecture of alveoli become thickened, hampering efficient diffusion of oxygen, as seen in diseases like idiopathic pulmonary fibrosis (IPF). LÄS MER

  4. 3. Cancer associated fibroblasts and T cells in pancreatic cancer : an immune perspective

    Författare :Laia Gorchs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : About 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC) and its deadly hallmarks, including a prominent fibrotic stroma, low mutational burden, lack of early diagnosis and rapid metastasis, contribute to trial failures and to the poor five-year overall survival rate of only 9%. Carcinoma associated fibroblasts (CAFs) are the most abundant cell type in the stroma of PDAC and their interactions with tumor cells leading to tumor progression have been extensively studied. LÄS MER

  5. 4. A personalized approach to chronic rhinosinusitis with nasal polyps : based on biomarkers, phenotypes and new surgical thinking

    Författare :Karin Jonstam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic rhinosinusitis (CRS) is a prevalent disease causing a substantial burden for the patient and the society. CRS is divided into CRS with (CRSwNP) and without nasal polyps (CRSsNP). LÄS MER

  7. 5. Transplantation of normal and decellularized syngeneic, allogeneic and xenogeneic cardiac tissue in mice and non-human primates

    Författare :Ketaki Methe; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Decellularization; Cardiac tissue; Syngeneic; Allogeneic; Xenogeneic; Non-human primate;

    Sammanfattning : Introduction Because of the restricted inherent capacity of regeneration and healing, transplantation is the only treatment for end-stage heart failure but it has limitations of donor shortage and graft rejection. Cardiac tissue engineering strategies might help to alleviate this problem. LÄS MER