Sökning: "perilymph"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet perilymph.

  1. 1. Inner ear proteomics and barriers : Clinical and experimental findings

    Författare :Jesper Edvardsson Rasmussen; Göran Laurell; Per Olof Eriksson; Helge Rask-Andersen; Jonas Bergquist; Måns Magnusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vestibular schwannoma; Hearing loss; Inner ear; Proteome; Perilymph; Endolymph; Furosemide; NKCC1; Fetuin-A; Complement component factor-H realted protein 2; CFHR2; Inflammation; MRI; Oto-Rhino-Laryngology; Oto-rhino-laryngologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Hearing is important in many aspects of life, including communication, assessing one’s surroundings, entertainment and social interaction. Hearing loss is common and according to the Global Burden of Disease Study, 5% of the global population require hearing rehabilitation (1). LÄS MER

  3. 2. Development of analytical methods for the determination of the small molecule component of complex biological systems

    Författare :Kristian Pirttilä; Mikael Hedeland; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; metabolomics; data processing; peak characterization; algorithm; multivariate data analysis; chromatography; sequential columns; HILIC; RPLC; liquid chromatography; mass spectrometry; LC; MS; noise-induced hearing loss; NIHL; guinea pig; perilymph; method development; validation; R; C ; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. LÄS MER

  4. 3. Pharmacokinetics and inner ear transport of cisplatin

    Författare :Victoria Hellberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Cisplatin is a commonly used platinum anti-cancer drug. Regrettably cisplatin has dose-limiting ototoxic side effects, e.g. the drug can induce an irreversible hearing loss. LÄS MER

  5. 4. Influence of middle ear pressure changes on labyrinthine hydrodynamics and hearing physiology

    Författare :Konrad Konradsson; Lund näs- och halssjukdomar Öron-; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; auditive system and speech; audiology; Pressure; Audiometry; Cats; Animal; Cochlea; Cochlear aqueduct; Ear; Eustachian tube; Hearing; Otorinolaryngologi; Human; Labyrinth; Otorhinolaryngology; Meniere s disease; audiologi; hörsel- och talorganen;

    Sammanfattning : Results from experimental studies, as well as clinical studies, are used to elucidate the effects of ambient pressure changes on cochlear hydrodynamics and function. The perilymph pressure changes and the pressure release effects of the cochlear aqueduct (CA) and Eustachian tube (ET) in cats exposed to hypobaric pressure are elucidated. LÄS MER

  7. 5. Prevention and intervention therapies in auditory trauma

    Författare :Anette Fransson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hearing impairment is one of the most common health conditions in developed countries. It is estimated that approximately 70 million people worldwide are deaf. For patients with a severe to profound hearing loss a cochlear implant (CI) is the only treatment today. LÄS MER