Sökning: "peptidylarginine deiminase"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden peptidylarginine deiminase.

  1. 1. Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases

    Författare :Bodil Roth; Gastroenterologi; []
    Nyckelord :multiple sclerosis; pathogenesis; peptidylargininedeiminase; transglutaminase.; Sjögren’s syndrome; autoimmune; Alzheimer’s disease;

    Sammanfattning : Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified. LÄS MER

  3. 2. On Generation and Function of Neutrophil Extracellular Traps in Abdominal Sepsis

    Författare :Avin Hawez; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Abdominal sepsis; inflamation; neutrophil; neutrophil extracellular traps; mRNA; adhesion.;

    Sammanfattning : AbstractSepsis is a clinical condition that develops when the immune system over-response to an infection. Sepsis can lead to organ failure as well as subsequent death. Sepsis-induced host response involves neutrophil over activation which can lead to self tissue damage. LÄS MER

  4. 3. An exPADItion for citrullination in the developing hair follicle

    Författare :Kim Vikhe Patil; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During epidermal development, to assure proper tissue structure, highly complex transcriptional networks interact within the stem cell compartments of the epidermis and hair follicles (HFs) to balance the choice between self-renewal or differentiation. The full characterisation of the protein profiles resulting from those transcriptional networks, within the compartments of the HF, remains, however, incomplete. LÄS MER

  5. 4. Studies on the relationship between periodontitis and rheumatoid arthritis

    Författare :Kaja Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Periodontitis and rheumatoid arthritis (RA) are both widespread multifactorial diseases, characterized by chronic inflammation leading to tissue and bone destruction around teeth or joints, respectively. An association between periodontitis and RA has been proposed, suggesting that the periodontal pathogen Porphyromonas gingivalis (P. LÄS MER

  7. 5. Post-translational and therapy-induced modifications in rheumatoid arthritis

    Författare :Dimitrios Makrygiannakis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial proliferation and excessive mononuclear infiltration leading to destruction of bone and cartilage, with subsequent joint deformities and physical disability. Even though RA etiology is still unknown, autoantibody driven pathogenic mechanisms are considered to be important, with strong evidence for the pathogenic potentials of antibodies directed against citrullinated antigens. LÄS MER