Sökning: "peptidomics"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet peptidomics.

1. 1. Neuropeptidomics – Methods and Applications

   Författare :Karl Sköld; Per E Andrén; Per Svenningsson; Chris Shaw; Uppsala universitet; []
   Nyckelord :Pharmaceutical pharmacology; mass spectrometry; proteomics; peptidomics; neuropeptide; bioinformatics; Farmaceutisk farmakologi;

   Sammanfattning : The sequencing of genomes has caused a growing demand for functional analysis of gene products. This research field named proteomics is derived from the term proteome, which by analogy to genome is defined as all proteins expressed by a cell or a tissue. LÄS MER

3. 2. Molecular Profiling and Imaging of Peptides, Proteins and Drugs in Biological Tissue using Mass Spectrometry

   Författare :Anna Nilsson; Per E. Andrén; Garry Corthals; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptidomics; mass spectrometry; liquid chromatography; MALDI imaging; neuropeptides; drugs; brain; Pharmacology; Farmakologi;

   Sammanfattning : Biological functions within cells and organisms are mainly carried out by the translational products; proteins and peptides. The analysis and characterization of these biomolecules are of great importance for the progress in disease research and biomarker and drug discovery. LÄS MER

4. 3. Neuropeptidomics – Expanding Proteomics Downwards

   Författare :Marcus Svensson; Per Andrén; Per Svenningsson; Jonathan Sweedler; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; proteomics; peptidomics; mass spectrometry; neuropeptide; chromatography; Farmaceutisk farmakologi; PHARMACY; FARMACI;

   Sammanfattning : Biological function is mainly carried out by a dynamic population of proteins which may be used as markers for disease diagnosis, prognosis, and as a guide for effective treatment. In analogy to genomics, the study of proteins is called proteomics and it is generally performed by two-dimensional gel electrophoresis and mass spectrometric methods. LÄS MER

5. 4. Cerebrospinal fluid peptidomics: discovery of endogenous peptides as biomarkers of Alzheimer's disease

   Författare :Karl Hansson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Biomarkers; Mass spectrometry; Cerebrospinal fluid; Liquid Chromatography; Endogenous peptides;

   Sammanfattning : Neurodegenerative diseases (NDs), the most prominent example of which is Alzheimer’s disease (AD), has turned out to be among the greatest challenges for modern medicine. Common characteristics of NDs involve the aggregation of proteins, progressive loss of neuronal cells in specific regions of the central nervous system (CNS) and as a result – cognitive and/or functional decline. LÄS MER

7. 5. Genomic and Peptidomic Characterization of the Developing Avian Brain

   Författare :Birger Scholz; Lennart Dencker; Eric Vilain; Uppsala universitet; []
   Nyckelord :Toxicology; Sex differentation; Sex determination; Sex chromosomes; Dosage Compensation; Genetic; Chickens; Coturnix; Gene Expression Profiling; Neuropeptides; Diencephalon; Toxikologi;

   Sammanfattning : Chicken and Japanese quail are commonly used models in developmental and sex specific neuroendocrine research. There is relatively little known about the mechanisms behind their sex specific brain development, especially regarding the impact of the sex chromosomes (male: ZZ, female ZW) in relation to gonadal hormones. LÄS MER