Sökning: "peptide-phage display"

Hittade 4 avhandlingar innehållade orden peptide-phage display.

  1. 1. Using peptide-phage display to capture conditional motif-based interactions

    Författare :Gustav Sundell; Ylva Ivarsson; Per Jemth; Attila Reményi; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interaction; PDZ domain; phosphorylation; peptide-phage display; ProP-PD; phospho-peptide; phosphomimetic substitution; Scribble; NMR; DLG1; PTM; affiinity; Biokemi; Biochemistry;

    Sammanfattning : This thesis explores the world of conditional protein-protein interactions using combinatorial peptide-phage display and proteomic peptide-phage display (ProP-PD). Large parts of proteins in the human proteome do not fold in to well-defined structures instead they are intrinsically disordered. LÄS MER

  2. 2. Identification of SLiMs: Mapping and characterizing motif-based protein interactions

    Författare :Muhammad Ali; Ylva Ivarsson; Shoshana Wodak; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Phage display; protein-protein interactions; short linear motifs; PDZ; FERM; affinity; x-ray crystallization; molecular docking; NLS;

    Sammanfattning : During the last twenty years it has become evident that about 35-40% of amino acids in the proteome are in regions that have evolved to remain unstructured. These intrinsically disordered regions contain short linear motifs (SLiMs), which serve as docking sites for protein-protein interactions. LÄS MER

  3. 3. Bacteriophages and cryogels: A new efficient tool in bioseparation

    Författare :Wim Noppe; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biopanning; Cryogel; Phage Display Technology; Chromato-panning;

    Sammanfattning : Abstract Due to developments in the last decades in the field of protein production, new technologies for bio-separation have evolved. Especially in the field of affinity chromatography, the search for new ligands is of great interest. Besides the antibodies used as affinity ligands, synthetic ligands were introduced. LÄS MER

  4. 4. Multiple Functions of Glutathione Transferases : A Study on Enzymatic Function, Regulatory Role and Distribution in Mouse and Man

    Författare :Maryam Edalat; Joseph De Pierre; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : To cope with various endogenous toxin and xenobiotics nature has equipped the organisms with a proper protection system. Glutathione transferases (GSTs) are important components of the cellular defense against oxidative stress. These proteins appear to be suited for different tasks. LÄS MER