Sökning: "peptide inhibitor"
Visar resultat 16 - 20 av 151 avhandlingar innehållade orden peptide inhibitor.
16. Renal effects of C-peptide in experimental type-1 diabetes mellitus
Sammanfattning : The incidence and prevalence of diabetic nephropathy are increasing continuously, mainly due to the increase in type-2 diabetes. In contrast, the risk of diabetic nephropathy for the individual patient has decreased considerably in recent decades due to improved glycemic control, successful treatment of hypertension and hyperlipidemia and the use of renin angiotensin system inhibitors, which have protective effects beyond those on blood pressure. LÄS MER
17. Molecular basis and pharmacological implications of Alzheimer amyloid ß-peptide fibril formation
Sammanfattning : Alzheimer's disease is a progressive neurodegenerative disease, mostly affecting elderly. The invariable deposition of protease-resistant fibrils of Alzheimer amyloid ß-peptide (Aß) in the parenchyma and blood vessels of the brain is a central event. LÄS MER
18. Pathogen-host interactions at the surface of Streptococcus pyogenes
Sammanfattning : The bacterial surface can be thought of as the interface where pathogenic bacteria encounter the human host. Interactions between bacterial surface proteins and human proteins are important determinants of the eventual outcome of infection. LÄS MER
19. Structural and Functional Studies of Chagasin, a Parasite Protease Inhibitor
Sammanfattning : The cysteine proteases are enzymes found in every kingdom of life. Clan CA is the largest of the cysteine protease clans, with members all displaying a Cys/His/Asn(Asp) catalytic triad responsible for hydrolysing the peptide bond within the substrate. LÄS MER
20. Design and Synthesis of Malarial Aspartic Protease Inhibitors
Sammanfattning : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. LÄS MER