Sökning: "peptide expression"

Visar resultat 1 - 5 av 532 avhandlingar innehållade orden peptide expression.

1. 1. Into the Membrane and Beyond : Improving Membrane Protein Over-Expression in Escherichia coli

   Författare :Mirjam Klepsch; Jan-Willem de Gier; Reinhard Grisshammer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; membrane protein over-expression; proteomics; T7 RNA polymerase; peptide transport; strain engineering; Biochemistry; Biokemi; Biophysical chemistry; Biofysikalisk kemi; biokemi; Biochemistry;

   Sammanfattning : Membrane proteins fulfil a wide variety of essential functions in the cell and many are (potential) drug targets. Since their natural abundance is usually very low, most membrane proteins have to be over-expressed for functional and structural studies. LÄS MER

3. 2. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

   Författare :Carmine Pasquale Cerrato; Ülo Langel; Lena Mäler; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. LÄS MER

4. 3. Preeclampsia – Studies on the Placenta and B-type Natriuretic Peptide

   Författare :Katja Junus; Matts Olovsson; Anna-Karin Wikström; Stefan Hansson; Liv Cecilie Vestrheim Thomsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BNP; B-type natriuretic peptide; early-onset preeclampsia; gene expression; NT-proBNP; placenta; preeclampsia; trophoblasts; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Sammanfattning : Preeclampsia has several pathophysiological pathways, but the placenta has a central role. The pathophysiology appears to differ between the two subtypes – early- and late-onset preeclampsia. LÄS MER

5. 4. Eosinophil Cationic Protein : Expression Levels and Polymorphisms

   Författare :Jonas Byström; Helene Rosenberg; Uppsala universitet; []
   Nyckelord :Medical sciences; Eosinophils; Neutrophils; Monocytes; Macrophages; mRNA; eosinophil cationic protein; DNA; polymorphism; Hodgkin Lymphoma; asthma; allergy; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Chemistry; klinisk kemi;

   Sammanfattning : The eosinophil cationic protein (ECP) is usually associated with the eosinophil granulocyte. In this thesis the presence and production of this protein has been studied in two other cells. The circulating monocyte was found to contain ECP mRNA and small amounts of ECP, one thousand times less than that found in the eosinophil. LÄS MER

7. 5. Regulation of antimicrobial peptide gene expression in Drosophila melanogaster : Involvement of POU and NF-kB/Rel factors in innate immunity

   Författare :Anna Junell; Ylva Engström; Jean-Luc Imler; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : The fruit fly, Drosophila melanogaster, has a well-developed immune response, and microbial assault induces a rapid production of potent antimicrobial peptides (AMPs). The aim of this thesis work was to gain deeper knowledge of the regulation of AMPs in Drosophila, by the isolation and characterization of transcription factors involved in AMP gene expression. LÄS MER