Sökning: "peptidases"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet peptidases.

  1. 1. Molecular mechanisms involved in prokaryotic cycling of labile dissolved organic matter in the sea

    Författare :Benjamin Pontiller; Jarone Pinhassi; Daniel Lundin; Catherine Legrand; Martin F. Polz; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bacteria and archaea; labile dissolved organic matter; metatranscriptomics; monomers; polymers; carbohydrate-active enzymes CAZymes ; peptidases; membrane transporters; Natural Science; Naturvetenskap; Akvatisk ekologi; Aquatic Ecology; Mikrobiologi; Microbiology;

    Sammanfattning : Roughly half of the global primary production originates from microscopic phytoplankton in marine ecosystems, converting carbon dioxide into organic matter. This organic matter pool consists of a myriad of compounds that fuel heterotrophic bacterioplankton. LÄS MER

  3. 2. Kallikrein-related peptidases in human epidermis : studies on activity, regulation, and function

    Författare :Kristina Stefansson; Torbjörn Egelrud; Maria Brattsand; Mona Ståhle; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; desquamation; epidermis; stratum corneum; kallikrein-related peptidase; KLK; serine protease inhibitors; Dermatology and venerology; Dermatologi och venerologi;

    Sammanfattning : Introduction. The outermost layer of the epidermis, the stratum corneum (SC), plays a fundamental role in our defense against microorganisms, chemicals, and dehydration. The SC is composed of tightly packed keratinized skin cells, corneocytes. For a functioning skin it is essential that corneocytes are constantly shed (desquamated). LÄS MER

  4. 3. Structural and Functional Studies on Human Type 2 Cystatins

    Författare :Marcia Alvarez Fernandez; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; structural- functional relationships.; protein crystallography; enzyme kinetics; inhibitors; cathepsins; legumains; cystatins; cysteine peptidases;

    Sammanfattning : Proteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. LÄS MER

  5. 4. The Kallikrein-Related Peptidases hK2 and PSA with Emphasis on Genetic Variation, Secretion, and Sperm Motility

    Författare :Charlotta Sävblom; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human glandular kallikrein 2; KLK3; hk2; prostate-specific antigen; PSA; sperm motility; seminal plasma; androgen receptor; SNP; CAG; KLK2;

    Sammanfattning : Prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) are secreted by the prostate into seminal plasma and through leakage into blood. This leakage increases rapidly in prostate disease, and PSA is used worldwide as a marker of prostate cancer. LÄS MER

  7. 5. Theoretical Modeling of Enzyme Catalysis with Focus on Radical Chemistry

    Författare :Vladimir Pelmenschikov; Per E. M. Siegbahn; Tim Clark; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; density functional theory; enzyme catalysis; radical chemistry; zinc-containing peptidase; methyl-coenzyme M reductase; ribonucleotide reductase; superoxide dismutase; Quantum chemistry; Kvantkemi;

    Sammanfattning : Hybrid density functional theory (DFT) B3LYP method is applied to study the four diverse enzyme systems: zinc-containing peptidases (thermolysin and stromelysin), methyl-coenzyme M reductase, ribonucleotide reductases (classes I and III), and superoxide dismutases (Cu,Zn- and Ni-dependent enzymes). Powerfull tools of modern quantum chemistry are used to address the questions of biological pathways at their molecular level, proposing a novel mechanism for methane production by methyl-coenzyme M reductase and providing additional insights into hydrolysis by zinc peptidases, substrate conversion by ribonucleotide reductases, and biological superoxide dismutation. LÄS MER