Sökning: "pentofuranose chemistry"

Hittade 1 avhandling innehållade orden pentofuranose chemistry.

1. 1. Novel Pentofuranose Chemistry to Modulate RNA Function

   Författare :Mansoureh Karimiahmadabadi; Jyoti Chattapadhyaya; Jesper Wengel; Uppsala universitet; []
   Nyckelord :pentofuranose chemistry; conformationally locked nucleoside; carbocyclic-LNA; bicyclo[2.2.1]heptane;

   Sammanfattning : Chemical modifications of oligonucleotides provide an important tool to understand how the natural substrate works as well as how to improve their biochemical and biological properties as potential therapeutics and diagnostics. Our carba-LNA (2',4'-carba-bridged Locked Nucleic Acid) modified oligo-DNA or -RNA have been found to be useful to modulate oligo-RNA and -DNA activity. LÄS MER