Sökning: "penicillin-binding proteins"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden penicillin-binding proteins.

  1. 1. From Penicillin Binding Proteins to Community Interventions : Mathematical and Statistical Models Related to Antibiotic Resistance

    Författare :Patricia Geli Rolfhamre; Åke Svensson; Mikael Andersson; Dan I. Andersson; Karl Ekdahl; Bruce R. Levin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; mathematical modeling; pharmacokinetics; pharmacodynamics; penicillin binding protein; postantibiotic effect; reversibility; selection; community intervention; Mathematical statistics; Matematisk statistik; matematisk statistik; Mathematical Statistics;

    Sammanfattning : Antibiotic resistance has become a major public health concern and mathematical models are important analytical tools for the understanding, evaluation and prediction of the resistance problem and related control strategies.The risk of emerging antibiotic resistance and selection has rarely been a concern in the design of antibiotic drug dosing regimens. LÄS MER

  3. 2. On the role of penicillin-binding protein SpoVD in endospore cortex assembly

    Författare :Ewa Bukowska-Faniband; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sporulation; cortex; Bacillus subtilis; penicillin-binding proteins; SpoVD; peptidoglycan;

    Sammanfattning : Bacteria of the genera Bacillus and Clostridium can form endospores as a strategy to survive unfavourable environmental conditions. Endospore formation involves synthesis of cortex, a thick layer of modified peptidoglycan that surrounds the spore. LÄS MER

  4. 3. Mechanisms and Dynamics of Mecillinam Resistance in Escherichia coli

    Författare :Elisabeth Thulin; Dan I Andersson; Laura Piddock; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mecillinam; Antibiotic resistance; Escherichia coli; Urinary tract infections; Fitness; Penicillin binding proteins; cysteine biosynthesis; Mikrobiologi; Microbiology;

    Sammanfattning : The introduction of antibiotics in healthcare is one of the most important medical achievements with regard to reducing human morbidity and mortality. However, bacterial pathogens have acquired antibiotic resistance at an increasing rate, and due to a high prevalence of resistance to some antibiotics they can no longer be used therapeutically. LÄS MER

  5. 4. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli

    Författare :Marlen Adler; Linus Sandegren; Josep Casadesús; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

    Sammanfattning : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. LÄS MER

  7. 5. Beta-lactam and metronidazole resistance in the Bacteroides fragilis group

    Författare :Hong Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bacteroides fragilis group; beta-lactam; metronidazole; resistance; beta-lactamase; penicillinbinding proteins PBPs ; outer membrane proteins OMPs ;

    Sammanfattning : The Bacteroides fragilis group organisms are anaerobic gram-negative bacilli. Ten species are currently included in this group. Members of the B. fragilis group are the major constituents of the normal colonic microflora and the most commonly encountered anaerobic bacteria in clinical specimens. LÄS MER