Sökning: "pemeability"

Hittade 1 avhandling innehållade ordet pemeability.

1. 1. Drug Dissolution under Physiologically Relevant Conditions In Vitro and In Vivo

   Författare :Eva Persson; Hans Lennernäs; Bertil Abrahamsson; Peter Langguth; Uppsala universitet; []
   Nyckelord :Biopharmacy; solubility; drug dissolution; food effects; poorly soluble drugs; P-gp inhibition; drug absorption; pemeability; bile acids; phospholipids; human intestinal fluid; simulated intestinal fluid; neutral lipids; solid phase extraction; HPLC; Efflux; Biofarmaci;

   Sammanfattning : The general aim of the present project was to increase the understanding of the in vivo dissolution of poorly soluble drugs and thereby improve possibility to predict in vivo solubility from substance properties. Increased understanding of the in vivo limitations of drug solubility could potentially also generate ideas for improved formulation principles for poorly soluble compounds and more relevant in vitro dissolution test methods used in formulation development. LÄS MER