Sökning: "pattern recognition proteins"

Visar resultat 11 - 15 av 49 avhandlingar innehållade orden pattern recognition proteins.

1. 11. Recognition and clearance of Streptococcus pneumoniae by the innate immune system

   Författare :Katharina Beiter; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Streptococcus pneumoniae (the pneumococcus) is a major human pathogen causing diseases such as pneumonia, bacteremia or meningitis and constitutes a leading cause of morbidity and mortality worldwide. The pathogenesis of pneumococcal disease and the mechanisms of recognition and clearance of S. LÄS MER

3. 12. Immune recognition molecules in synaptic plasticity and regeneration of spinal motoneurons

   Författare :Sebastian Thams; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis is based on the emerging concept that pattern recognition molecules, originally characterized in the immune system, may be expressed and used by neurons to mediate non-immune functions. In line with this concept, the major histocompatibility complex (MHC) class I and certain complements proteins have been implicated in synaptic plasticity in the developing visual system. LÄS MER

4. 13. Regulation of Adenoviral Gene Expression by the L4-33K and L4-22K Proteins

   Författare :Ellenor Backström; Göran Akusjärvi; Francoise Raffalli-Mathieu; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Virologi; Medical Virology; Medicinsk virologi;

   Sammanfattning : The splicing pattern during an adenovirus infection is shifted at the late phase towards using weaker splice sites, splicing out larger introns. Splicing of weak 3´ splice sites usually requires recognition of the 3´AG dinucleotide before the first catalytic step of splicing. LÄS MER

5. 14. CD8+ T cell specificity in thymic selection and in the recognition of antigen

   Författare :Johan Sandberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :T cell; specificity; MHC class 1; selection; tolerance;

   Sammanfattning : Specificity mediated by the T cell receptor (TCR) is of fundamental importance for the ability of T cells to function, and regulate humoral immunity and effector mechanisms of the innate immune system. T cells recognize composite molecules consisting of products of the major histocompatibility complex (MHC) class I or class 11 loci, in complex with a short peptide fragment derived from endogenous or antigenic proteins. LÄS MER

7. 15. Structural characterization of proteins to investigate their roles in diseases: Focus on MID & LTA4H

   Författare :Mahmudul Hasan; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Moraxella IgD binding protein; adhesin; leukotriene A4 hydrolase; small angle x-ray scattering; crystallography; circular dichroism;

   Sammanfattning : Protein molecules are responsible for many biological functions in cells. In order to fulfill their various biological roles, these chain-like molecules must fold into precise three-dimensional shapes. The knowledge of accurate molecular structures is a prerequisite for rational drug design and for structure based functional studies. LÄS MER