Sökning: "patrick augustijns"

Hittade 3 avhandlingar innehållade orden patrick augustijns.

1. 1. Drug Transport and Metabolism in Rat and Human Intestine

   Författare :Sofia Berggren; Hans Lennernäs; Janet Hoogstraate; Patrick Augustijns; Uppsala universitet; []
   Nyckelord :Biopharmacy; Ussing chamber; microsome; single-pass perfusion; human; rat; intestine; permeability; efflux; P-glycoprotein; metabolism; cytochrome P450; ropivacaine; lidocaine; bupivacaine; Biofarmaci; PPX;

   Sammanfattning : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. LÄS MER

3. 2. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment

   Författare :Sara Carlert; Hans Lennernäs; Bertil Abrahamsson; Patrick Augustijns; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

   Sammanfattning : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. LÄS MER

4. 3. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

   Författare :Sibylle Neuhoff; Per Artursson; Anna-Lena Ungell; Patrick Augustijns; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Caco-2 cells; membrane permeability; drug permeation; drug efflux ratios; drug uptake ratios; Cremophor EL; bovine serum albumin; pH-dependent permeability; drug transport; FARMACI; PHARMACY; FARMACI;

   Sammanfattning : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. LÄS MER