Sökning: "patologisk anatomi"
Visar resultat 6 - 10 av 25 avhandlingar innehållade orden patologisk anatomi.
6. Morphological Features and Mismatch Repair in Colorectal Tumors
Sammanfattning : Corlorectal cancer affects 5% of individuals in the Western world and heredity is estimated to cause at least 10% of the tumors. Defective mismatch repair (MMR) is a tumorigenic mechanism through which about 15% of colorectal cancer develops and this feature characterizes tumors associated with Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch syndrome. LÄS MER
7. Radial head and neck fractures
Sammanfattning : All elbow fractures between 1969 – 1979 (n=2965) registered at the radiographic archives at the Malmö University Hospital, where all radiographs are saved since a century, were evaluated. Fractures of the radial head and neck were classified according to the by Broberg and Morrey modified Mason classification. LÄS MER
8. Aggressive lymphoma
Sammanfattning : Aggressive lymphoma is a rapidly growing tumour of lymphocyte origin, potentially curable with chemotherapy. In a trial by the Nordic Lymphoma Group, 405 patients with aggressive lymphoma were included, and randomised to receive either the standard chemotherapy regimen, CHOP, or a weekly multidrug regimen, MACOP-B. LÄS MER
9. TISSUE MICROARRAY PERSPECTIVES ON CYCLIN D1 IN BREAST CANCER: Progression, prognosis and prediction
Sammanfattning : Breast cancer is a truly heterogenous disease, reflected in the existence of a wide spectrum of phenotypic subsets of tumours with varying intrinsic aggressiveness as well as ability to respond to a given treatment. Recent advances in large-scale genomic and proteomic screening techniques have confirmed this heterogeneity also at a molecular level, but there is still a bottleneck to be overcome before the discoveries in the laboratory can be translated into the much more complex clinical situation in order to develop better targeted therapies. LÄS MER
10. Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
Sammanfattning : Estrogen receptor (ER) status can define breast cancer patients who would benefit from adjuvant tamoxifen therapy. However, resistance to tamoxifen is often observed and possible mechanisms may be loss or reduction of ER, dysfunctional ER- signaling and ligand independent activation of the receptor. LÄS MER