Sökning: "patient-derived models"
Visar resultat 6 - 10 av 43 avhandlingar innehållade orden patient-derived models.
6. New targeted therapies for malignant neural tumors : From systematic discovery to zebrafish models
Sammanfattning : Cancers in the neural system presents a major health challenge. The most aggressive brain tumor in adults, glioblastoma, has a median survival of 15 months and few therapeutic options. High-risk neuroblastoma, a childhood tumor originating in the sympathetic nervous system, has a 5-year survival under 50%, despite extensive therapy. LÄS MER
7. Experimental models of pediatric brain tumors. Establishment, immunophenotyping and clinical implications
Sammanfattning : Brain tumors are the most common solid tumors in children. Current treatment protocols fail in 25% of patients and are associated with significant long-term adverse effects in survivors. LÄS MER
8. Stem cell-based models to study cellular alterations in Parkinson’s Disease
Sammanfattning : Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. LÄS MER
9. Developing new models of childhood malignancies using human induced pluripotent stem cells
Sammanfattning : Early onset diseases such as childhood malignancies and neurodevelopmental disorders have been intricate to study. For many years, research has relied and dependent upon different animal systems. LÄS MER
10. Hypoxia and Stem Cells in Normal and Tumor Development
Sammanfattning : Neuroblastoma is a childhood malignancy of the sympathetic nervous system and accounts for 15% of all cancer-related deaths in children. To understand the biology behind neuroblastoma, clarify timing of cellular events and expression profiles of proteins preceding neuroblastoma initiation, we need more relevant preclinical models. LÄS MER