Sökning: "patient-derived models"

Visar resultat 11 - 15 av 43 avhandlingar innehållade orden patient-derived models.

  1. 11. Towards personalized immunotherapy : development of in vitro models for imaging natural killer cell behavior in the tumor microenvironment

    Författare :Valentina Carannante; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tremendous advances in the tumor immunology field have transformed immunotherapy from a promising approach to a standard clinical practice. However, a subset of cancer patients is non-responsive to immunotherapy. More research is therefore needed to understand the mechanisms underlying tumor resistance to immunotherapeutic treatments. LÄS MER

  3. 12. Development of individualized surgical treatments for malignant melanoma

    Författare :Valerio Belgrano; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; sentinel node; isolated limb perfusion; immune-humanized xenograft mouse models; translational research;

    Sammanfattning : Background: Cutaneous melanoma is a malignancy with an increasing incidence worldwide, especially in northern Europe. The aim of this thesis is to scrutinize the results achieved by traditional surgery and the opportunities offered by translational research for the more advanced stages of the disease. LÄS MER

  4. 13. Complex genomic rearrangements in rare brain disorders : genetic architecture and molecular consequences

    Författare :Jakob Schuy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Structural variants (SVs) within the genome, such as deletions, duplications, inversions, and translocations, are common but underappreciated causes of rare diseases. Complex genomic rearrangements involving two or more SVs in cis are incredibly challenging to detect. LÄS MER

  5. 14. SOD, ORF and ALS: On the role of SOD1 and C9ORF72 in the pathogenesis of ALS

    Författare :Isil Keskin; Peter M. Andersen; Lars Lannfelt; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; Misfolded species;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is characterized by adult-onset degeneration of upper and lower motor neurons. Symptoms begin focally in one muscle and then spread contiguously, resulting in progressive paralysis and death from respiratory failure. LÄS MER

  7. 15. Exploring Patient-Specific Cell Replacement Therapy for Parkinson's Disease

    Författare :Shelby Shrigley; Utvecklings- och regenerativ neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopaminergic neurons; Parkinson s disease; cell replacement therapy; cellular reprogramming; alpha-synuclein;

    Sammanfattning : Parkinson’s disease (PD) affects over six million people worldwide and is characterised by the progressive loss of dopaminergic (DA) neurons in the substantia nigra, accumulation of pathological alpha-synuclein (αSyn), and inflammation in the brain. This leads to motor impairments including rigidity, akinesia, bradykinesia, resting tremor, and postural instability. LÄS MER