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Visar resultat 1 - 5 av 242 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Statistical Feature Selection : With Applications in Life Science

   Författare :Roland Nilsson; Jesper Tegnér; Johan Björkegren; Sepp Hochreiter; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Machine learning; supervised learning; classification; dimemsionality reduction; multiple testing; gene expression; microarray; cancer; Bioinformatics; Bioinformatik;

   Sammanfattning : The sequencing of the human genome has changed life science research in many ways. Novel measurement technologies such as microarray expression analysis, genome-wide SNP typing and mass spectrometry are now producing experimental data of extremely high dimensions. LÄS MER

3. 2. Esophageal and Gastroesophageal Junctional Cancer : Improving Patient selection, Treatment and Care

   Författare :Christine Jestin Hannan; Jakob Hedberg; Gustav Linder; Magnus Sundbom; Guillaume Piessen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; Lymphadenectomy; Geographical differences; Atelectasis; Multidisciplinary Cancer Conference;

   Sammanfattning : Esophageal cancer is the sixth most common cause of cancer-related death. Choice of surgical approach and individualized treatment is crucial. The aims of this thesis were to evaluate the introduction of minimally invasive esophagectomy (MIE) regarding oncological results and postoperative complications. LÄS MER

4. 3. Covariate Model Building in Nonlinear Mixed Effects Models

   Författare :Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
   Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

   Sammanfattning : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. LÄS MER

5. 4. Uvulopalatopharyngoplasty : patient selection, long- term outcomes, and side effects

   Författare :Joar Sundman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Uvulopalatopharyngoplasty (UPPP) is the most common surgical treatment for adult patients with obstructive sleep apnea (OSA). Its short-term efficacy, as measured through polysomnography, is well-established and has been demonstrated in two randomized controlled trials in recent years. LÄS MER

7. 5. Surveys and services : The feasibility of conducting research in Swedish community pharmacies

   Författare :Pia Frisk; Sofia Kälvemark-Sporrong; Margareta Hammarlund-Udenaes; Björn Wettermark; Marcel L Bouvy; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Community pharmacy; Pharmaceutical services; Drug utilization research; Survey; Patient; Pharmaceutical care; Feasibility; Sweden; Social Pharmacy; Samhällsfarmaci;

   Sammanfattning : For the past decades, there has been a shift in community pharmacy practice from dispensing and compounding towards provision of pharmacy services. Research is important to generate evidence for new services within pharmacy practice. LÄS MER