Sökning: "pathway"

Visar resultat 1 - 5 av 2139 avhandlingar innehållade ordet pathway.

  1. 1. Global functional association network inference and crosstalk analysis for pathway annotation

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Christoph Ogris; Stockholms universitet.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Sammanfattning : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. LÄS MER

  2. 2. Polyamine Pathway as Drug Target against Malaria

    Detta är en avhandling från Biogenic Amines

    Författare :Janina Sprenger; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amino acid insertions; Crystallography; polyamine pathway; drug design; enzyme inhibition; ITC; ligand binding; malaria; Plasmodium falciparum; S-Adenosylmethionine decarboxylase; spermidine synthase.;

    Sammanfattning : Popular Abstract in English An algae that has lost its ability to do photosynthesis over the last million years and started to feed on human blood causes about 600.000 death every year, a number equals about 8 times Lund’s present population. LÄS MER

  3. 3. Nitric Oxide Reductase from Paracoccus denitrificans A Proton Transfer Pathway from the “Wrong” Side

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Ulrika Flock; Stockholms universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; denitrification; nitric oxide reductase; heme copper oxidase superfamily; divergent member; proton transfer; electron transfer; single turnover; spectroscopy; periplasm; glutamate; proton pathway; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Sammanfattning : Denitrification is an anaerobic process performed by several soil bacteria as an alternative to aerobic respiration. A key-step in denitrification (the N-N-bond is made) is catalyzed by nitric oxide reductase (NOR); 2NO + 2e- + 2H+ → N2O + H2O. LÄS MER

  4. 4. Enzymes in the Mycobacterium tuberculosis MEP and CoA Pathways Targeted for Structure-Based Drug Design

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Christofer Björkelid; Uppsala universitet.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Tuberculosis; Mycobacterium tuberculosis; MEP pathway; CoA pathway; drug development; crystal structure; DXR; IspD; PanK; Biokemi; Biochemistry; Molecular Biology; Molekylärbiologi;

    Sammanfattning : Tuberculosis, caused by the pathogenic bacteria Mycobacterium tuberculosis, is one of the most widespread and deadly infectious diseases today. Treatment of tuberculosis relies on antibiotics that were developed more than 50 years ago. These are now becoming ineffective due to the emergence of antibiotic resistant strains of the bacteria. LÄS MER

  5. 5. Genetic modeling of the Hippo pathway in hematopoietic stem cells

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Lina Jansson; Lunds universitet.; Lund University.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cells; hematopoiesis; Hippo pathway; hematopoietic stem cells;

    Sammanfattning : Popular Abstract in Swedish I vår kropp genereras konstant ett stort antal nya blodceller för att ersätta de som går förlorade. Olika sorters blodceller är ansvariga för att transportera syre till alla våra vävnader, hjälpa till med blodets koagulering vid skador och att slåss mot infektioner orsakade av bakterier och virus. LÄS MER