Sökning: "pathway"

Visar resultat 1 - 5 av 2649 avhandlingar innehållade ordet pathway.

  1. 1. Global functional association network inference and crosstalk analysis for pathway annotation

    Författare :Christoph Ogris; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. LÄS MER

  3. 2. Pathway analysis: methods and perspectives

    Författare :Gustavo Stolf Jeuken; Lukas Käll; Mika Gustafsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pathway analysis; mutual information; survival analysis; enrichment analysis; transcriptomics.; Biotechnology; Bioteknologi;

    Sammanfattning : The amount of data being generated by high throughput molecular biology experiments grows every day, both in quantity and quality. With this comes the desire to have more powerful and comprehensive methods for statistical analysis that have been developed with the nature of this data in mind. LÄS MER

  4. 3. Mevalonate pathway end-products : metabolism, utilization and regulation

    Författare :Anders Thelin; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  5. 4. Polyamine Pathway as Drug Target against Malaria

    Författare :Janina Sprenger; Biogena aminer; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amino acid insertions; Crystallography; polyamine pathway; drug design; enzyme inhibition; ITC; ligand binding; malaria; Plasmodium falciparum; S-Adenosylmethionine decarboxylase; spermidine synthase.;

    Sammanfattning : Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 death cases every year. Mainly affected are populations of subtropical countries in Africa and the largest groups of victims are children below the age of 5 years. LÄS MER

  7. 5. Nitric Oxide Reductase from Paracoccus denitrificans : A Proton Transfer Pathway from the “Wrong” Side

    Författare :Ulrika Flock; Pia Ädelroth; Simon de Vries; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; denitrification; nitric oxide reductase; heme copper oxidase superfamily; divergent member; proton transfer; electron transfer; single turnover; spectroscopy; periplasm; glutamate; proton pathway; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Denitrification is an anaerobic process performed by several soil bacteria as an alternative to aerobic respiration. A key-step in denitrification (the N-N-bond is made) is catalyzed by nitric oxide reductase (NOR); 2NO + 2e- + 2H+ → N2O + H2O. LÄS MER