Sökning: "pathway analysis"

Visar resultat 6 - 10 av 728 avhandlingar innehållade orden pathway analysis.

1. 6. Metabolic analysis of shikimic acid producing Escherichia coli

   Författare :Louise Johansson; Avdelningen för kemiteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kemiteknik och kemisk teknologi; Biokemi; metabolism; Chemical technology and engineering; transcriptome analysis; phosphorus-limitation; carbon-limitation; fed-batch; chemostat; batch; fermentation technology; Escherichia coli; shikimic acid; Biotechnology; Bioteknik; Metabolism; Biochemistry; principal component analysis; 2D-fluorescence spectrophotometry; metabolic flux analysis; carbon-rich;

   Sammanfattning : Shikimic acid production using recombinant E.coli has been developed during the past 15 years due to the increased demand of this product, primarily as a starting material for the anti-influensa medicine Tamiflu?. A detailed metabolic analysis of a shikimic acid producing E. LÄS MER

3. 7. Systems Biology Based Approaches to Identify Biomarkers in Seasonal Allergic Rhinitis

   Författare :Hui Wang; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucocorticoids; Seasonal allergic rhinitis; Biomarkers; Gene expression microarray analysis; Proteomics; Multivariate analysis; Pathway analysis;

   Sammanfattning : Glucocorticoids (GC) are the most effective anti-inflammatory treatment for seasonal allergic rhinitis (SAR). However, a few patients with SAR show poor response to GC treatment. Hence, there is a clinical need to find biomarkers to predict and monitor treatment response. LÄS MER

4. 8. Proximity Ligation Assays for Disease Biomarkers Analysis

   Författare :Rachel Yuan Nong; Ulf Landegren; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; blood biomarkers; protein interactions; pathway analysis; single molecule; next-generation sequencing; Molekylär medicin; Molecular Medicine;

   Sammanfattning : One of the pressing needs in the field of disease biomarker discovery is new technologies that could allow high performance protein analysis in different types of clinical material, such as blood and solid tissues. This thesis includes four approaches that address important limitations of current technologies, thus enabling highly sensitive, specific and parallel protein measurements. LÄS MER

5. 9. Protein targeting, translocation and insertion in Escherichia coli : Proteomic analysis of substrate-pathway relationships

   Författare :Louise Baars; Jan-Willem de Gier; Jan-Maarten van Dijl; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein biogenesis; targeting; translocation; insertion; SecB; SecE; E. coli; Biochemistry; Biokemi; biokemi; Biochemistry;

   Sammanfattning : Approximately 10% of the open reading frames in the genome of the Gram-negative bacterium E. coli encodes secretory proteins, and 20% encodes integral inner membrane proteins (IMPs). LÄS MER

7. 10. Big data networks and orthology analysis

   Författare :Emma Persson; Erik Sonnhammer; Albert László Barabási; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ortholog; protein domain; functional association network; pathway enrichment analysis; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

   Sammanfattning : Understanding biological systems in complex organisms is important in life science in order to comprehend the interplay of genes, proteins, and compounds causing complex diseases. As biological systems are intricate, bioinformatics tools, models, and algorithms are of the utmost importance to understand the bigger picture and decipher biological meaning from the vast amounts of information available from biological experiments and predictions. LÄS MER