Sökning: "pathway analysis"

Visar resultat 11 - 15 av 728 avhandlingar innehållade orden pathway analysis.

1. 11. Systems Analysis of the Protein Secretory Pathway in Yeast and Human Cells

   Författare :Amir Feizi; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein production; flux balance analysis; biopharmaceutical; secretory pathway: secretome; recombinant protein; genome-scale modeling; systems biology;

   Sammanfattning : The cell was discovered by Robert Hooke in 1665, later in nineteen century the cell theory was developed as all organisms are composed of one or more cells. Since then, many tools and experimental methods have been developed to dissect and characterize the cell components which resulted in established solid scientific fields such as biochemistry, molecular cell biology and genetics. LÄS MER

3. 12. Computational Analysis of Tumour Heterogeneity

   Författare :Stefanie Friedrich; Erik Sonnhammer; Martin Hemberg; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tumour heterogeneity; human genome and gene expression analyses; pathway annotation; fusion transcript detection; copy number calling; and high-resolution data; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological signature. The diversity observed between and within tumours, and over time, is termed tumour heterogeneity. An increased heterogeneity within a tumour correlates with cancer progression, higher resistance rates, and poorer outcome. LÄS MER

4. 13. Exploring the Genetics of SLE with Linkage and Association Analysis

   Författare :Cecilia Johansson; Marta Alarcón-Riquelme; Peter Gregersen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic lupus erythematosus; complex disease; linkage analysis; association analysis; Genetik; Genetics; Genetik;

   Sammanfattning : The aim with this thesis has been to identify genes involved in the pathogenesis of Systemic Lupus Erythematosus (SLE). SLE is a systemic autoimmune disorder, most likely caused by both several genetic and environmental factors. LÄS MER

5. 14. Advanced Machine Learning Methods for Oncological Image Analysis

   Författare :Mehdi Astaraki; Chunliang Wang; Örjan Smedby; Iuliana Toma-Dasu; Bjoern Menze; KTH; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Medical Image Analysis; Machine Learning; Deep Learning; Survival Analysis; Early Response Assessment; Tumor Classification; Tumor Segmentation; Medicinsk teknologi; Medical Technology;

   Sammanfattning : Cancer is a major public health problem, accounting for an estimated 10 million deaths worldwide in 2020 alone. Rapid advances in the field of image acquisition and hardware development over the past three decades have resulted in the development of modern medical imaging modalities that can capture high-resolution anatomical, physiological, functional, and metabolic quantitative information from cancerous organs. LÄS MER

7. 15. Applied Bioinformatics in Saccharomyces cerevisiae: Data storage, integration and analysis

   Författare :Kwanjeera Wanichthanarak; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; gene expression analysis; database system; database design; integrative analysis;

   Sammanfattning : The massive amount of biological data has had a significant effect on the field of bioinformatics. This growth of data has not only lead to the growing number of biological databases but has also imposed the needs for additional and more sophisticated computational techniques to proficiently manage, store and retrieve these data, as well as to competently help gaining biological insights and contribute to novel discoveries. LÄS MER