Sökning: "pathological oxidation"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden pathological oxidation.

  1. 1. Alpha-1-microglobulin: Innate defence against pathological oxidation

    Författare :Magnus Gram; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-1-microglobulin; pathological oxidation; hemoglobin; heme; radiation; oxidation; ROS; hemoglobin and heme antagonist; radical scavenger;

    Sammanfattning : Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. LÄS MER

  3. 2. Mechanisms and treatment options of chronic graft dysfunction : Experimental and clinical studies

    Författare :Lilija Zezina; Uppsala universitet; []
    Nyckelord :Medical sciences; chronic graft dysfunction; kidney transplantation; aorta transplantation; lipid oxidation; LDL; TGF-beta; Smad2; angiotensin II receptor; treatment; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Chronic graft dysfunction (CGD) is an important post-transplant complication. CGD can be considered as an impaired repair process, which ultimately leads to the loss of graft function.To study non-immunological factors contributing to the development of CGD in kidney grafts we used in vitro and in vivo models, and clinical studies. LÄS MER

  4. 3. PTPs : redox controlled regulators of cell signaling and transformation

    Författare :Åsa Sandin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein tyrosine phosphatases (PTPs) are important redox regulated enzymes that control the tyrosine phosphorylation status in the cell. These studies aimed to increase the understanding on how PTPs are controlled by reversible oxidation in different pathological settings such as hypoxia and restenosis and to which extent oxidized PTPs contribute to certain diseases. LÄS MER

  5. 4. Therapeutic opportunities of alpha-1-microglobulin A study in placenta, blood, skin and eye

    Författare :Martin Cederlund; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reactive oxygen species; hemoglobin; myeloperoxidase; oxidative stress; α1-microglobulin;

    Sammanfattning : This thesis describes functional studies of the human protein alpha-1-microglobulin (A1M), with the aim of exploring its usefulness as a therapeutic agent in diseases where oxidative stress is a prominent feature. A1M is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding antioxidative functions. LÄS MER

  7. 5. β-cell dysfunction in Huntington's disease

    Författare :Karl Bacos; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; secretion; Insulin; trafficking; R6 2 mouse; granule; exocytosis; neurodegeneration; huntingtin;

    Sammanfattning : Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocrine dysfunction. LÄS MER