Sökning: "parkinson s"

Visar resultat 1 - 5 av 57 avhandlingar innehållade orden parkinson s.

1. 1. Imaging neurochemical changes associated with Parkinson´s disease and L-DOPA-induced dyskinesia using mass spectrometry

   Författare :Elva Fridjonsdottir; Per E. Andrén; Miles Trupp; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; Parkinson´s disease; L-DOPA-induced dyskinesia;

   Sammanfattning : Parkinson’s disease (PD), caused by a loss of midbrain dopamine neurons, is the second most common neurodegenerative disease worldwide after Alzheimer’s disease. The primary treatment choice for PD is L-DOPA, the precursor for dopamine, which only affects symptoms and does not inhibit disease progression. LÄS MER

3. 2. Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells- for replacement therapy in Parkinson´s disease

   Författare :Jenny Nelander Wahlestedt; Utvecklings- och regenerativ neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson´s disease; stem cells; ventral mesencephalon; dopaminergic neurons; cell replacement therapy; human fetal tissue; radial glia; microRNA; BAC recombineering; reporter cell lines;

   Sammanfattning : Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. LÄS MER

4. 3. Wearable sensors for monitoring epilepsy and Parkinson´s disease

   Författare :Dongni Johansson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Parkinson’s disease; Wearable sensors; Continuous and objective monitoring; End users’ perceptions; Qualitative content analysis; Machine learning algorithms; Tonic-clonic seizure detection; Dose titration; Motor state recognition;

   Sammanfattning : Introduction: Epilepsy and Parkinson’s disease (PD) are conditions where management would benefit greatly from monitoring symptoms over longer time periods in natural everyday environments instead of only intermittent assessments at clinics. Wearable technology with built-in sensors such as accelerometers and gyroscopes, could allow continuous and objective long-term monitoring of movement patterns. LÄS MER

5. 4. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2

   Författare :Elin Andersson; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; cell replacement; Parkinson?s; dopamine; neuronal specification; development; mesencephalon; TH; neuronal differentiation; proneural genes; transcription factors; bHLH; neurospheres; stem cell; progenitor cell;

   Sammanfattning : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. LÄS MER

7. 5. Self-management support to handle everyday life with Parkinson´s disease

   Författare :Carina Hellqvist; Carina Berterö; Peter Hagell; Märtha Sund-Levander; Nil Dizdar Segrell; Stefan Sävenstedt; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; self-management; everyday life; self-care support; care partners; self-management intervention;

   Sammanfattning : Background: Being diagnosed with Parkinson´s disease (PD) is a life-altering experience. The long-term condition requires continuous adjustments to the everyday life not only of the person affected, but also for care partners. LÄS MER