Avancerad sökning

Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Genetic and molecular regulation of epithelial tube morphogenesis

    Författare :Anna Tonning; Göteborgs universitet; []
    Nyckelord :epithelial tube morphogenesis; trachea; Drosophila; chitin; chitin synthase; apical extracellular matrix; paracellular diffusion barrier; tube expansion; septate junctions;

    Sammanfattning : Networks of epithelial tubes, such as the vertebrate lung, kidney and vascular system, enable transport of gases and nutrients to all tissues in the body. These tubes are built up by a single layer of polarized epithelial cells, with the apical membrane facing the lumen. LÄS MER

  3. 2. Mechanisms for leukocyte-mediated adjustment of endothelial barrier function

    Författare :Narinder Gautam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Inflammation; leukocyte extravasation; endothelial cells; vascular permeability; plasma leakage integrin signaling; heparin binding protein; contact phase; bradykinin.;

    Sammanfattning : Extravasation of polymorphonuclear leukocytes (PMN) and associated plasma exsudation are key events in the inflammatory process. The mechanism by which activated PMN may induce increased vascular permeability for macromolecules is not fully understood but crucially dependent on an intact leukocytic beta2 integrin (CD11/CD18) adhesion receptor function. LÄS MER

  4. 3. Genetic variation of tight junction structures in intestinal inflammation

    Författare :Elisabeth Norén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The epithelial barrier facing the external environment in the gastrointestinal (GI) tract is comprised of several components, including the tight junction (TJ) structures observed for the first time in 1963. TJ structures, which are multiprotein complexes composed of transmembrane proteins and a diverse spectrum of intracellular components, create a primary barrier to diffusion of ions, solutes, and water and they concomitantly prevent permeation of pro-inflammatory factors, such as pathogens, toxins, and antigens. LÄS MER