Sökning: "pancreatic islet transplantation"
Visar resultat 6 - 10 av 42 avhandlingar innehållade orden pancreatic islet transplantation.
6. The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease
Sammanfattning : Diabetes Mellitus is a group of complex and heterogeneous metabolic disorders characterized by hyperglycemia. Even though the condition has been extensively studied, its causes and complex pathologies are still not fully understood. The occurring damage to the pancreatic islets is strikingly heterogeneous. LÄS MER
7. Neogenesis and alloxan toxicity in pancreatic islets, with special reference to the transplanted human β-cell
Sammanfattning : The aim of this work was to study whether adult human pancreatic β-cells have the capacity to proliferate in culture and after transplantation to the renal subcapsular space of mice. An immunosuppressive regimen for human islet discordant xenotransplantation to mice was designed. LÄS MER
8. Leukocytes in Angiogenesis : Learning from Transplanted Pancreatic Islets
Sammanfattning : Angiogenesis, the growth of new blood vessels, is a complex process involving several cell types and molecular signals. Excessive vascular growth is a problem in tumors, and insufficient vascularization hampers the function of transplanted insulin-producing pancreatic islets. LÄS MER
9. Studies of Regulatory T cells with Implications for Clinical Applications
Sammanfattning : Regulatory T cells (Tregs) are vital for regulating immune homeostasis and for preventing immunopathology. The immunosuppressive functions of Tregs have raised hope for their potential use in clinical applications. LÄS MER
10. Experimental Studies Aiming to Prevent Type 1 Diabetes Mellitus
Sammanfattning : Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which T-cells and macrophages invade the islets of Langerhans and selectively destroy the insulin producing β-cells, either directly or through the secretion of e.g. cytokines and nitric oxide (NO). This thesis has studied possible strategies to prevent T1DM. LÄS MER