Sökning: "pancreatic beta cell"

Visar resultat 6 - 10 av 155 avhandlingar innehållade orden pancreatic beta cell.

1. 6. Protein tyrosine kinases in insulin producing cells : Expression and putative importance for beta-cell function

   Författare :Charlotte Öberg-Welsh; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Protein tyrosine kinase; insulin producing cells; fetal development; VEGF; Src-family; Bsk; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : Protein tyrosine kinases are of importance for cell replication and differentiation in manysystems. The mechanisms controlling the replication and differentiation of insulin producingcells are unknown. LÄS MER

3. 7. Microencapsulation of Pancreatic Islets : A Non-Vascularised Transplantation Model

   Författare :Sara Bohman; Arne Andersson; Aileen King; Stellan Sandler; Eduard Montanya; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microencapsulation; Islet transplantation; revascularisation; alpha-cell; exendin-4; islet amyloid; Cell biology; Cellbiologi;

   Sammanfattning : Transplantation of pancreatic islets is a potential treatment of type 1 diabetes that aims to restore normal blood glucose control. By encapsulating the islets in alginate, they can be protected from rejection. LÄS MER

4. 8. Engraftment of Pancreatic Islets in Alternative Transplantation Sites and the Feasibility of in vivo Monitoring of Native and Transplanted Beta-Cell Mass

   Författare :Daniel Espes; Per-Ola Carlsson; Joey Lau; Mia Phillipson; Eelco de Koning; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Islet transplantation; Alternative implantation sites; Exendin-4; Positron Emission Tomography; 5-hydroxy tryptophan; Beta-cell mass; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Islet transplantation is a possible curative treatment for type 1 diabetes (T1D). Currently the liver dominates as implantation site, despite the many challenges encountered at this site.Acute hypoxia in islets transplanted to muscle and omentum, two possible alternative sites, was prevailing. LÄS MER

5. 9. Palmitate-induced Apoptosis in Insulin-producing β-cells

   Författare :Kristofer Thörn; Peter Bergsten; Claes Wollheim; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ER stress; apoptosis; palmitate; sphingosine-1-phosphate; ceramide; beta-cell; fatty acid; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Type 2 diabetes is a disease characterized by the inability of pancreatic β-cells to secrete sufficient amounts of insulin to maintain normoglycemia. Increased levels of saturated fatty acids such as palmitate are believed to contribute to β-cell failure and the development of the disease. LÄS MER

7. 10. Oscillatory Signaling and Insulin Secretion from Single ß-cells

   Författare :Olof Idevall Hagren; Anders Tengholm; Erik Gylfe; Leslie Satin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; Ca2 ; oscillations; beta-cell; insulin secretion; evanescent wave microscopy; PIP3; PKA; Epac; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. LÄS MER