Sökning: "pancreatic beta cell"
Visar resultat 11 - 15 av 154 avhandlingar innehållade orden pancreatic beta cell.
11. Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function
Sammanfattning : Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. LÄS MER
12. Study of the Proliferation, Function and Death of Insulin-Producing Beta-Cells in vitro: Role of the Transcription Factor ZBED6
Sammanfattning : A thorough understanding of beta-cell proliferation, function, death and regeneration under normal condition as well as in the progression of diabetes is crucial to the conquest of this disease. The work presented in this thesis aimed to investigate the expression and role of a novel transcription factor, Zinc finger BED domain-containing protein 6 (ZBED6), in beta-cells. LÄS MER
13. Challenges in Islet Transplantation and Strategies to Improve Beta-Cell Function
Sammanfattning : The incidence of type 1 diabetes is increasing worldwide and therapies of islet transplantation and potential cell-based therapies are rapidly evolving. Choosing the optimal site for such therapies is crucial for safety and for obtaining the best possible outcome. LÄS MER
14. Somatostatin Receptor Expression and Biological Functions in Endocrine Pancreatic Cells
Sammanfattning : Type 1 diabetes is resulting from the selective destruction of insulin-producing beta-cells within the pancreatic islets. Somatostatin acts as an inhibitor of hormone secretion through specific receptors (sst1-5). LÄS MER
15. Role of Thrombospondin-1 in Endogenous and Transplanted Pancreatic Islets
Sammanfattning : Type 1 diabetes mellitus is a severe life-long disease with a pronounced risk of developing secondary complications. One way to avoid the latter is to restore the fine tuning of blood glucose homeostasis by transplantation of pancreatic islets. LÄS MER