Sökning: "pancreatic [beta]-cell oscillations"

Hittade 5 avhandlingar innehållade orden pancreatic [beta]-cell oscillations.

  1. 1. Oscillatory Signaling and Insulin Secretion from Single ß-cells

    Författare :Olof Idevall Hagren; Anders Tengholm; Erik Gylfe; Leslie Satin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; Ca2 ; oscillations; beta-cell; insulin secretion; evanescent wave microscopy; PIP3; PKA; Epac; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. LÄS MER

  3. 2. Models of the metabolism of the pancreatic beta-cell

    Författare :Pål Westermark; Anders Lansner; Jean-Pierre Mazat; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computer science; Computer science; Datalogi;

    Sammanfattning : The pancreatic β-cell secretes insulin in response to a raised blood glucose level. Deficiencies in this control system are an important part of the etiology of diabetes. LÄS MER

  4. 3. Metabolic signals and the ATP-sensitive potassium channel in the pancreatic beta-cell

    Författare :Robert Bränström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP-regulated K channel; pancreatic [beta]-cell oscillations; [alpha]-ketoisocaproate; long chain acyl-CoA esters; Kir6.2 SUR1 structure-function.;

    Sammanfattning : ATP-sensitive K+ (KATP) channels are widely distributed in a variety of tissues and cell types. KATP channels are comprised of two subunits, a pore forming subunit (Kir6.x) and a regulatory sulfonylurea receptor (SURx). Both subunits are required for fully functional channels. LÄS MER

  5. 4. Effects of over-stimulation by glucose on pancreatic beta-cell functioning : studies in vitro with diazoxide

    Författare :Anneli Björklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :diabetes mellitus; diazoxide; hyperglycemia; insulin secretion; islets of Langerhans; over-stimulation;

    Sammanfattning : Long term hyperglycemia impairs pancreatic ß-cell function. In vivo studies in rats have shown a decreased glucose-induced insulin response in the perfused pancreas after high glucose infusions. LÄS MER

  7. 5. Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations

    Författare :Dominic-Luc Webb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis examined parameters influencing stimulated cytoplasmic free Ca2+ concentration ([Ca2+]i) oscillations in hepatocytes and pancreatic beta-cells. Hepatic glucose output is regulated in part by hormones such as vasopressin that act through [Ca 2+]i oscillations. LÄS MER