Sökning: "pain modulation"

Visar resultat 1 - 5 av 66 avhandlingar innehållade orden pain modulation.

  1. 1. Acetylcholine in Spinal Pain Modulation : An in vivo Study in the Rat

    Författare :Klas Abelson; Urban Höglund; Ernst Brodin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Laboratory animals; Pain; Nociception; Antinociception; Acetylcholine; Muscarinic; Nicotinic; Spinal cord; Microdialysis; Försöksdjursvetenskap; Laboratory animal science; Försöksdjursvetenskap;

    Sammanfattning : The spinal cord is an important component in the processing and modulation of painful stimuli. Nerve signals from the periphery are relayed and further conducted to the brain (nociception) in the spinal cord, and the most essential modulation of painful information (antinociception) occurs here. LÄS MER

  3. 2. Central nervous modulation of pain - a clinical and experimental study

    Författare :Christopher Lundborg; Göteborgs universitet; []
    Nyckelord :pain; head and neck; cisterna magna; baroreflex; noradrenaline; GDNF; co-cultured astrocytes; naloxon; osteoarthritis; calcium;

    Sammanfattning : This series of studies addresses several conceptual issues in modern pain therapy related to the contemporary understanding of mechanisms and modulators involved in the pain sensation. Novel invasive therapy for severe pain, neurogenic interactions, humoral regulators and cellular responses were studied. LÄS MER

  4. 3. Neuropeptides, sensory neurons and pain modulation

    Författare :Pablo R Brumovsky; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the present thesis work we have analyzed the expression, regulation and function of two neuropeptides: galanin and neuropeptide tyrosine (NPY). Their associated receptors, galanin receptor-1 and -2 (GaIR1, -R2) and NPY Y1- and Y2R, were also studied. LÄS MER

  5. 4. Towards a Translational Pain Model - Techniques and developments

    Författare :Leila Etemadi; Neuronano Research Center (NRC); []
    Nyckelord :UVB irradiation; Pain; Neuropeptides; Inflammation; Contralateral; Lateral spinal nucleus; Micro-array electrodes; Pan-neuronal markers; immunohistochemistry;

    Sammanfattning : Pain is a major health issue for each affected individual and has a large impact on health costs. Most of our knowledge about this defensive system rely on data from different animal experiments. There is an obvious need for a translational pain model allowing comparisons between experimental animals and humans. LÄS MER

  7. 5. Experimental nerve injury : induced pain : mechanisms and modulation

    Författare :Johan Wallin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic nerve injury-induced pain presents a therapeutic challenge since such pain is often resistant to conventional analgesic drugs including opioids. Better knowledge of the pathophysiological mechanisms underlying nerve injuryinduced pain is necessary to develop new and more efficacious therapies. LÄS MER