Sökning: "pS2"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet pS2.

  1. 1. Molecular mechanisms of estrogen and antiestrogen action

    Författare :Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

    Sammanfattning : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. LÄS MER

  3. 2. Annealing of Cu2ZnSn(S,Se)4 Thin Films : A Study of Secondary Compounds and Their Effects on Solar Cells

    Författare :Yi Ren; Charlotte Platzer-Björkman; Maarja Grossberg; Uppsala universitet; []
    Nyckelord :Annealing; sputtering; thin film; CZTS; secondary phases; solar cell; Engineering Science; Teknisk fysik;

    Sammanfattning : Kesterite Cu2ZnSnS4 (CZTS) is interesting as a sustainable photovoltaic technology due to its earth-abundant elements and suitable semiconducting properties. To date, a record efficiency of 12.6% has been achieved but further improvements are required to reach high efficiency for industrial implementation. LÄS MER

  4. 3. Different types of γ-secretes complexes and their effect on substrate processing

    Författare :Annelie Pamrén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide (Aβ) from the amyloid precursor protein (APP). The γ-secretase complex cleaves APP at two different sites (γ- and ε-sites) generating Aβ-peptides and the APP intracellular domain (AICD). LÄS MER

  5. 4. Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling

    Författare :Nodi Dehvari; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) and Parkinson's disease (PD) are the major neurodegenerative disorders affecting the elderly. The discovery of genes causing familial forms of these disorders has contributed enormously towards our understanding of underlying pathogenic mechanisms. LÄS MER

  7. 5. Studies of presenilin function in neurodegeneration and in human embryonic CNS during development

    Författare :Beata Kostyszyn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity for cleaving transmembrane proteins such as the amyloid precursor protein (APP), Notch receptors and ligands. LÄS MER