Sökning: "p70s6k"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet p70s6k.

1. 1. Glucose- and hypoxia-regulated insulin gene expression

   Författare :Linda Tillmar; Jens Höiriis Nielsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islet; beta-cell; insulin; mRNA stability; PTB; glucose; hypoxia; mTOR; p70s6k; ceramide; redox; ROS; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : Although extensively studied, there are still many unanswered questions regarding the exact regulation of insulin gene expression. This is important to further investigate since it will hopefully help us understand the pathophysiology of some types of diabetes. LÄS MER

3. 2. Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease

   Författare :Wen-Lin An; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alzheimer s disease; p70 S6 kinase; tau; protein translation; accumulation; phosphorylation;

   Sammanfattning : One of the important neuropathological features of Alzheimer's disease (AD) is the tau pathology seen as accumulation and hyperphosphorylation of this protein. Evidences showed that tau could be phosphorylated mostly at serine/threonine (S/T) residues by many kinases, including protein kinase B, glycogen synthase kinase (GSK)-3beta, extracellular signal-regulated kinase (ERK1/2), ERK1/2 kinase (MEK1/2), c-Jun Nterminal kinase (JNK), and p38. LÄS MER

4. 3. Tau and neurofilament proteins in Alzheimer’s disease and related cell models

   Författare :Cecilia Björkdahl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AD; tau; neurofilament proteins; kinases; zinc; Hsp27; alphaB-crystallin;

   Sammanfattning : Background and aims: Among those afflicted with dementia more than half suffer from Alzheimer’s disease (AD). Pathological hallmarks of the disease include aggregates of Abeta, so called amyloid plaques, and neurofibrillary tangles (NFTs) made up of hyperphosphorylated cytoskeletal proteins. LÄS MER

5. 4. Cyclic Nucleotide Phosphodiesterase 3B: Regulation in rat adipocytes and 3T3-L1 cells

   Författare :Tova Landström; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3T3-L1 TNF-alpha; adipocyte; insulin; p70S6 kinase; mitogen-activated protein kinase; protein kinase B; phosphatidylinositol-3 kinase; phosphodiesterase 3B; cAMP; lipolysis; phosphorylation; signal transduction; Biochemistry; Metabolism; Biokemi; metabolism;

   Sammanfattning : Insulin stimulation of rat adipocytes results in phosphorylation and activation of the cyclic nucleotide phosphodiesterase 3B (PDE3B), a key enzyme in the antilipolytic signalling pathway of this hormone. In this thesis, the site phosphorylated in PDE3B upon stimulation of rat adipocytes with insulin and/or the beta-adrenergic agonist, isoproterenol is identified. LÄS MER

7. 5. Basis for reclassification of nasopharyngeal carcinoma

   Författare :Jian-Yong Shao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Nasopharyngeal carcinoma (NPC) shows broad differences in racial and geographical distribution, radiosensitivity, and a multifactorial etiology. This thesis aims to identify molecular biomarkers with potentially valuable for prognostic implications in NPC. LÄS MER