Sökning: "p57Kip2"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet p57Kip2.

  1. 1. p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation

    Författare :Magnus Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :p57Kip2 ; g lucocorticoids; cell cycle; apoptosis; lung development; transcriptional regulation;

    Sammanfattning : Glucocorticoids (GCs), are steroid hormones with several important physiological implications, of which some are connected with the ability of GCs to inhibit cell proliferation. Although GC treatment normally accumulates cells in the GI phase of the cell cycle, the mechanisms behind this phenomenon are not well understood. LÄS MER

  3. 2. The many faces of p57Kip2 : acting in apoptosis, differentiation and cytoskeleton reorganisation

    Författare :Pinelopi Vlachos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : p57Kip2 is a known cyclin dependent kinase inhibitor, which has been suggested to be a tumor suppressor gene. Indeed various human cancers show a reduction in p57Kip2 expression, indicating that this protein might be of relevance in tumorigenesis. LÄS MER

  4. 3. On molecular mechanisms of neural differentiation and forebrain development

    Författare :Erik Södersten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Telencephalic development is an extraordinary complex process where neural structures of highly diverse cell compositions emerge as the result of multiple developmental strategies imposing tight regulation, balance and timing of gene expression. Embryonic telencephalic neural stem cells (NSCs) can form the major cell types found in the telencephalon, and are thus an excellent model for studying transcriptional control of lineage choice mechanisms in CNS development. LÄS MER

  5. 4. Some aspects of nuclear receptor function in the CNS : novel roles of Nurr1 and RXR in developing and mature neurons

    Författare :Åsa Wallén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear receptor superfamily comprises the receptors for steroid hormones, thyroid hormone, vitamin D and retinoids. The family also includes a number of receptors that lack identified ligands, and are therefore referred to as orphan receptors. LÄS MER

  7. 5. Transcriptional regulation of cell life and death decisions by p73

    Författare :Naveen Reddy Muppani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : p73 is the second member to be identified within the p53 family and shares structure and functions with p53. P73 generates various isoforms, which include full-length transcriptionally active (TA) isoforms and amino-terminal transactivation domain-deficient (ΔN) isoforms. LÄS MER