Sökning: "p53"

Visar resultat 16 - 20 av 402 avhandlingar innehållade ordet p53.

  1. 16. Understanding the role of long non-coding RNAs in neuroblastoma development and progression

    Författare :Sanhita Mitra; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Long non-coding RNAs; NBAT1; NRSF REST; CASC15; chromosome 6p22; SOX9; USP36; CHD7; p53; CRM1; MDM2;

    Sammanfattning : Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to NB tumor formation. LÄS MER

  3. 17. Prognostic Factors in Early Stages (FIGO I-II) of Epithelial Ovarian Carcinoma

    Författare :Ingirídur Skírnisdóttir; Seija Grenman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; Ovarian cancer; early stages; adjuvant therapy; prognosis; tumor grade; apoptotic regulators; p53; bcl-2; bax; growth factor receptors; HER-2 neu; EGFR; DNA ploidy; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; Obstetrics and Gynaecology; obstetrik och gynekologi;

    Sammanfattning : From January, 1988, to December, 1993, 113 patients with FIGO stage IA-IIC epithelial ovarian carcinoma were treated with postoperative radiotherapy. The median follow-up period was 74 months. Tumor recurrences were recorded in 33 cases (30%). The cancer-specific survival rate was 72%. LÄS MER

  4. 18. Studies of polyglutamine expanded Ataxin-7 toxicity

    Författare :Xin Yu; Anna-Lena Ström; Albert La Spada; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neurodegeneration; SCA7; protein degradation; aggregation; p53; oxidative stress; NOX; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant inherited neurodegenerative disease for which there is no cure. SCA7 belongs to the group of polyglutamine disorders, which are all caused by the expansion of a polyglutamine tract in different disease proteins. LÄS MER

  5. 19. The Columnar Lined Esophagus: aspects on the assessment of dysplasia and on the relationship with the esophageal submucosal glands

    Författare :Ester Lörinc; Malmö Klinisk patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Columnar lined esophagus; Barrett´s esophagus; submucosal gland; multilayered epithelium; p53; Ki67; CK17; skin appendage;

    Sammanfattning : Columnar metaplasia, where columnar epithelium replaces the normal squamous epithelium in esophagus, is considered to be a precancerous condition in which the development of adenocarcinoma can be followed through various grades of dysplasia. The interpretation of these histological changes is subjective and suffers from considerable inter-observer variation among pathologists. LÄS MER

  7. 20. On new and current treatments for Diamond-Blackfan anemia

    Författare :Sara Sjögren; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :Diamond-Blackfan anemia; Erythropoiesis; Ribosome biogenesis; Heme synthesis; Glucocorticoids; p53; Globin translation; HRI; a1-microglobulin;

    Sammanfattning : Diamond-Blackfan anemia (DBA) is a rare congenital disease where the patients suffer from macrocytic anemia due to reduced numbers of erythroid precursors in the bone marrow. Most patients carry mutations in ribosomal proteins, such as ribosomal protein S19 (RPS19), which causes deficient ribosome biogenesis and affects protein translation. LÄS MER