Sökning: "p53 antibodies"

Visar resultat 11 - 15 av 21 avhandlingar innehållade orden p53 antibodies.

  1. 11. Indicators of colorectal cancer prognosis and response to preoperative radiotherapy

    Författare :Gunnar Adell; Olof Lannerstad; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Colorectal cancer is one of the three most common malignant diseases in Sweden, with about 5,000 new cases each year. Thirty-five percent of these are rectal cancer, for which local recurrence after surgery has been a serious problem. The five-year survival rate in colorectal cancer has improved from about 40% in 1960 to 55% in 1995. LÄS MER

  3. 12. Ploidy, cell proliferation and apoptosis in lymphoid malignancies : methodological and clinical aspects

    Författare :Magdalena Czader; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :image cytometry; confocal cytometry; DNA ploidy; cell proliferation; ;

    Sammanfattning : The DNA aneuploidy and proliferative activity have been previously shown to carry a clinical significance in Iymphoid malignancies. However, the application of these parameters is complicated by methodological difficulties. LÄS MER

  4. 13. Old receptors learn new tricks : biasing anti-IGF1R cancer therapy through the GPCR system

    Författare :Dawei Song; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : As cancers progress, tumor cells exploit the extracellular signals generated from plasma membrane receptors for cell growth, migration, and anti-apoptosis. G protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTKs) are two important families of plasm membrane receptors, controlling multiple biological functions via their downstream signaling. LÄS MER

  5. 14. Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer

    Författare :Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes and loss of function mutations in tumor suppressor genes. LÄS MER

  7. 15. Synovial sarcoma : a Scandinavian sarcoma group project

    Författare :Björn Skytting; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :synovial sarcoma; prognosis; tumor size; poorly differentiated; histologic grading; Ki-67; proliferation; CGH; secondary aberrations; RT-PCR; translocation; SYT-SSX1 SYT-SSX2;

    Sammanfattning : Synovial sarcoma accounts for 5 to 10 % of all soft tissue sarcomas. More than 90 % are found in the extremities or trunk wall. Characteristic for synovial sarcoma is the translocation t(X; 18) (p11.2;q11. LÄS MER