Sökning: "p24"

Visar resultat 16 - 20 av 28 avhandlingar innehållade ordet p24.

  1. 16. Unifying viral evolution and immunological patterns to investigate risk of HIV-1 disease progression

    Författare :Melissa M Norström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : After 30 years of research, the exact mechanisms underlying human immunodeficiency virus type 1 (HIV-1) pathogenesis and disease progression remain elusive. In the absence of highly active antiretroviral therapy, most HIV-infected individuals progress to AIDS within 10 years. LÄS MER

  3. 17. On the role of dendritic cells in HIV-1 infection

    Författare :Anna Smed Sörensen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dendritic cell; plasmacytoid; myeloid; HIV-1; cytokines; co-stimulation; transmission; antigen presentation; apoptotic cells; MuLV;

    Sammanfattning : Dendritic cells (DCs) are antigen-presenting cells with the capacity to initiate primary T cell responses against pathogens such as HIV-1. In addition, DCs express the receptors required for HIV-1 infection and as DCs are prevalent in the mucosa, they encounter the virus early after sexual transmission. LÄS MER

  4. 18. Short modified peptides and their metabolites inhibit HIV replication

    Författare :Elin Andersson; Göteborgs universitet; []
    Nyckelord :HIV-1; AIDS; GPG-NH2; G-NH2; antiretroviral drugs; Dipeptidyl peptidase IV; CD26; prodrug;

    Sammanfattning : Several drugs inhibiting the replication of HIV-1, the causative agent of AIDS, are available today. However, HIV-1 treatment is hampered by side effects, poor adherence and development of resistance. LÄS MER

  5. 19. Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults

    Författare :Åsa Björndal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1 HIV-2 biological phenotype genetic subtype chemokine receptors disease progression monocyte-derived macrophages;

    Sammanfattning : Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and one of the chemokine receptors CCR1, CCR2b, CCR3, CCR5 or CXCR4, were infected with a panel of well-characterized primary HIV-1 isolates. LÄS MER

  7. 20. Regulation of gene and protein expression : two model systems

    Författare :Lars H Lund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; EIAV; Tat; TAR; Cyclin T1; CDK9; P-TEFb; RNA polymerase II; gene regulation; transcriptional elongation; CEA; signal sequence.;

    Sammanfattning : Genetic information is expressed by DNA transcription and mRNA translation. With few exceptions, every cell of an organism, or the human body, contains the same genetic information. Yet the structure and function of different tissues are highly variable. LÄS MER