Sökning: "p210 BCR-ABL"
Hittade 3 avhandlingar innehållade orden p210 BCR-ABL.
1. Molecular and functional studies of the BCR/ABL1 fusion gene
Sammanfattning : The BCR/ABL1 fusion gene is associated with chronic myeloid leukemia and a subgroup of acute lymphoblastic leukemia. The general aim of this thesis was to increase the understanding of BCR/ABL1-induced leukemogenesis by molecular and functional studies of this fusion gene. LÄS MER
2. Studies of leukotriene C4 synthase expression and regulation in chronic myeloid leukaemia
Sammanfattning : Leukotriene (LT) C4 is generated through conjugation of LTA4 with glutathione by the actions of leukotriene C4 synthase (LTC4S). This biologically potent mediator of asthma and inflammation has also been suggested to play a regulatory role in human myelopoiesis and is overproduced by blood and bone marrow cells from patients with chronic myeloid leukaemia (CML). LÄS MER
3. The SHB adaptor protein in human and murine leukemia
Sammanfattning : The SHB adaptor protein operates downstream of tyrosine kinase receptors. It has been found previously that Shb deficiency in hematopoietic stem cells (HSCs) results in less proliferation and failure to maintain the myeloid compartment over time. LÄS MER