Sökning: "p-AKT"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet p-AKT.
1. Diffuse large B-cell lymphoma – studies on immunohistochemical and clinical prognostic factors
Sammanfattning : DLBCL, the most common lymphoma entity, is a potentially curable but heterogeneous disease. Most studies concerning therapy and prognostic factors have been performed on selected patient materials. It is important to identify immunohistochemical biomarkers which could add prognostic information to clinical factors. LÄS MER
2. Filamin A in Cardiovascular Remodeling
Sammanfattning : Filamin A (FLNA) is a large actin-binding cytoskeletal protein that stabilizes actin networks and integrates them with cell membranes. FLNA is therefore important for cell motility and organ development. LÄS MER
3. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation
Sammanfattning : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. LÄS MER
4. Biological signature of HER2-positive breast cancer
Sammanfattning : Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers (HER2+ breast cancer) are associated with an aggressive disease course. This thesis is focused on improving the understanding of the biological signature of HER2+ breast cancer. LÄS MER
5. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer
Sammanfattning : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. LÄS MER
