Sökning: "oxysterol"

Visar resultat 26 - 28 av 28 avhandlingar innehållade ordet oxysterol.

1. 26. Cell response to imaging contrast agents suggested for atherosclerotic plaque imaging

   Författare :Amit Laskar; Ximing Yuan; Wei Li; Rolf GG Andersson; Eva Hurt-Camejo; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : Oxysterols are the major cytotoxic components of oxidized low-density lipoprotein (OxLDL) that accumulate in atherosclerotic plaques. Their uptake by macrophages ensue foam cell formation, atherogenesis and plaque progression. LÄS MER

3. 27. Genotype-phenotype characterization of familial hyperkinetic movement disorders : emphasis on ataxia and brain calcifications

   Författare :Martin Paucar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Differential diagnosis of familial chorea encompasses Huntington’s disease along with a group of conditions referred to as Huntington’s disease-like (HDL). One such HDL is an inherited prion disorder (IPD) caused by pathological insertions of 8 additional OPRIS in the prion protein gene (PRNP). LÄS MER

4. 28. 24s-Hydroxycholesterol : studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration

   Författare :Marjan Shafaati; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC). This structural modification allows 24S-OHC to traverse the blood brain barrier and this pathway is the major one for elimination of cholesterol from the mammalian brain. LÄS MER