Sökning: "oxysterol"
Visar resultat 26 - 28 av 28 avhandlingar innehållade ordet oxysterol.
26. Cell response to imaging contrast agents suggested for atherosclerotic plaque imaging
Sammanfattning : Oxysterols are the major cytotoxic components of oxidized low-density lipoprotein (OxLDL) that accumulate in atherosclerotic plaques. Their uptake by macrophages ensue foam cell formation, atherogenesis and plaque progression. LÄS MER
27. Genotype-phenotype characterization of familial hyperkinetic movement disorders : emphasis on ataxia and brain calcifications
Sammanfattning : Differential diagnosis of familial chorea encompasses Huntington’s disease along with a group of conditions referred to as Huntington’s disease-like (HDL). One such HDL is an inherited prion disorder (IPD) caused by pathological insertions of 8 additional OPRIS in the prion protein gene (PRNP). LÄS MER
28. 24s-Hydroxycholesterol : studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration
Sammanfattning : Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC). This structural modification allows 24S-OHC to traverse the blood brain barrier and this pathway is the major one for elimination of cholesterol from the mammalian brain. LÄS MER