Sökning: "oxysterol"

Visar resultat 11 - 15 av 28 avhandlingar innehållade ordet oxysterol.

  1. 11. Effects of hypoxia on macrophage function in atherosclerosis

    Författare :Ellen Knutsen Rydberg; Göteborgs universitet; []
    Nyckelord :atherosclerosis; hypoxia; macrophage; IL-8; oxidized LDL; oxysterols; 15-lipoxygenase-2;

    Sammanfattning : Atherosclerosis is a complex disease, which affects large and medium sized arteries and is characterized by an arterial wall thickening. A constant supply of oxygen is needed to maintain cell functions in the atherosclerotic plaque. The oxygen distribution to the cells in the arterial wall depends on diffusion. LÄS MER

  3. 12. Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol

    Författare :Hanna Nylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about 50% of all drugs. LÄS MER

  4. 13. Use of primary human hepatocytes for the elucidation of bile acid synthesis

    Författare :Ewa C S Ellis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the present investigation we cultured primary human hepatocytes on matrigel under serum-free conditions and studied bile acid formation. The following observations were made: · The major steroid products excreted from primary human hepatocytes into the culture medium were cholic acid, CA (70%) and chenodeoxycholic acid, CDCA (25%) conjugated with glycine or taurine. LÄS MER

  5. 14. Steroids and steroid-metabolizing enzymes in the nervous system : Special focus on cell survival and sex hormone synthesis

    Författare :Ida Emanuelsson; Maria Norlin; Kjell Wikvall; Lena Ekström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Biochemistry;

    Sammanfattning : Some steroids in the brain and peripheral nervous system have been shown to have neuroprotective effects but the knowledge is limited. The present study examines the effects of steroids including oxysterols, vitamin D and vitamin D analogs on cell viability/growth and steroidogenesis in the nervous system. LÄS MER

  7. 15. Drug-based therapies for auditory trauma

    Författare :Anette Fransson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Deafness is one of the most common health conditions in the developed countries, and worldwide, an estimated 70 million people are deaf. For people with severe to profound hearing loss, a cochlear implant is the only treatment today. The most common forms of severe hearing loss and deafness are related to morphological changes in the cochlea. LÄS MER