Sökning: "oxybutynin"

Hittade 3 avhandlingar innehållade ordet oxybutynin.

  1. 1. The bladder and the brain : Studies on the pathogenesis and the treatment of nocturnal enuresis

    Författare :Tryggve Nevéus; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; nocturnal enuresis; children; desmopressin; osmoregulation; sleep; arousal; detrusor instability; incontinence; oxybutynin; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; pediatrik; Pediatrics;

    Sammanfattning : Opinions differ as to whether nocturnal enuresis is caused by high arousal thresholds, nocturnal polyuria or nocturnal bladder instability. In spite of the currently available therapeutic options - the antidiuretic drug desmopressin and alarm treatment - approximately 25% of children suffering from enuresis cannot be successfully treated. LÄS MER

  3. 2. Estimation of Dosing Strategies for Individualisation

    Författare :Siv Jönsson; Mats O. Karlsson; Leon Aarons; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Dosing strategy; Individualisation; Pharmacokinetic; Pharmacodynamic; Modeling; NONMEM; Decision making; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci;

    Sammanfattning : To increase the proportion of patients with successful drug treatment, dose individualisation on the basis of one or several patient characteristics, a priori individualisation, and/or on the basis of feedback observations from the patient following an initial dose, a posteriori individualisation, is an option. Efficient tools in optimising individualised dosing strategies are population models describing pharmacokinetics (PK) and the relation between pharmacokinetics and pharmacodynamics (PK/PD). LÄS MER

  4. 3. Generation of cell diversity in the developing brainstem and its modeling in vitro

    Författare :Mariya Kozhevnikova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional and temporal patterning provides a basic framework for how the developing brain can be functionally assembled, and the growing knowledge about these patterning mechanisms offer a powerful tool to effectively control the differentiation of pluripotent stem cells (PSCs) into different neuronal subtypes of clinical importance. LÄS MER