Sökning: "oxidized LDL"

Visar resultat 16 - 20 av 48 avhandlingar innehållade orden oxidized LDL.

1. 16. Circulating immune complexes in atherosclerotic vascular disease

   Författare :Awder Mustafa; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :circulating immune complexes; autoantibodies; lipoproteins; cardiolipin; oxidized LDL; atherosclerosis; myocardial infarction; food proteins; complement factor C4.;

   Sammanfattning : We have investigated the association of the humoral immune factors circulating immune complexes (CICs) and autoantibodies against cardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic vascular diseases. In a prospective nested case-control study, in which healthy 50-year-old men were followed for 20 years, the prevalence of elevated CICs and the concentration of CICs were higher in men who developed myocardial infarction. LÄS MER

3. 17. Immune mechanisms in atherosclerosis

   Författare :Ejaz Ahmed; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :atherosclerosis; diabetes; stroke; rheumatoid arthritis; autoantibodies; anticardiolipin; oxidized LDL; hypercholesterolernia; IFN-gamma TNF-alpha IL-1beta IL-1Ra.;

   Sammanfattning : Atherosclerosis is a multifactorial chronic inflammatory disorder. Humoral immune factors as anticardiolipin antibodies (aCL), anti-oxLDL antibodies, circulating immune complexes (CICs), and proinflammatory cytokines such as IFN-gamma, TNF-alpha and EL-1beta have been implicated in atherogenesis. LÄS MER

4. 18. Tumor necrosis factor-a in atherosclerosis

   Författare :Stefan Jovinge; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :atherosclerosis; oxidized low-density lipoprotein; monocytes; tumor necrosis factor-a; cytokinesis; ets-l; matrix metalloproteinases; apoptosis; glucose metabolism; insulin resistance; myocardial infarction;

   Sammanfattning : The presence of inflammatory cells is prominent at all phases of the atherosclerotic process leaving no doubt that the inflammation is of central importance in atherosclerosis. The recruitment of inflammatory cells into the vessel wall is therefore a key event in early lesion formation. LÄS MER

5. 19. The vascular response to oxidative and mechanical stress

   Författare :Federico Ben Calara; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :atherosclerosis; inflammation; smooth muscle cells; low density lipoprotein; oxidized low density lipoprotein; lipid peroxidation; antioxidants; HDL; caveolae; phenotype modulation; balloon injury; immunization; growth factors;

   Sammanfattning : Atherosclerosis is a chronic inflammatory disease, which is one of leading causes of death in the Western world. The study of the vascular response to initiators of inflammation can lead us to a better understanding of the basic mechanisms that lead to the development of this disease. Balloon injured arteries develop a neointima. LÄS MER

7. 20. Effects of lipid oxidation on transcriptional regulation and cell death

   Författare :Mikko Ares; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :atherosclerosis; low density lipoprotein; lipid oxidation; nuclear factor-KB; activator protein-1; Iysophosphatidylcholine; tumor necrosis factor-alpha; oxysterol; Ca2 ; apoptosis; lipid accumulation;

   Sammanfattning : Elevated levels of low density lipoprotein (LDL) in plasma are associated with an increased risk for atherosclerosis. Excessive accumulation of lipoproteins and lipids in the vascular wall is thought to lead to the development of advanced atherosclerotic lesions prone to rupture. LÄS MER