Sökning: "oxazolidinones"

Hittade 5 avhandlingar innehållade ordet oxazolidinones.

  1. 1. A Regio- and Stereodivergent Route to All Isomers of vic-Amino Alcohols

    Författare :Berit Olofsson; KTH; []
    Nyckelord :amino alcohols; vinylepoxides; vinylaziridines; oxazolines; oxazolidinones; ring-opening; regioselective; diastereoselective; sphingosine; configuration; NMR spectroscopy;

    Sammanfattning : The first part of this thesis describes a synthetic strategythat provides all eight possible isomers of a given vic-aminoalcohol starting from vinylepoxides. The value of a generalroute is evident, as several isomers are needed ininvestigations of structure-activity relationships forpharmacologically active derivatives, and for optimizing theperformance of chiral ligands containing the amino alcoholmoiety. LÄS MER

  3. 2. Palladium(II)-Catalyzed Oxidative Cyclization Strategies : Selective Formation of New C-C and C-N Bonds

    Författare :Andreas K. Å. Persson; Jan-Erling Bäckvall; Matthew Sigman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbocyclization; Palladium Catalysis; Oxidation; Cyclization; Enallenes; Aza-Enallenes; Dienallenes; Allenylation; Oxazolidinones; Biomimetic; Arylation; Borylation; Transmetallation; organisk kemi; Organic Chemistry;

    Sammanfattning : The main focus of this thesis has been directed towards preparation and oxidative carbocyclization of en-, dien- and aza-enallenes.In the first part of this thesis, a stereoselective oxidative carbocyclization of dienallenes was realized. LÄS MER

  4. 3. Development of Aerobic Oxidative N-Heterocyclic Carbene Catalysis via Multistep Electron Transfer and its Application

    Författare :Anton Axelsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; dihydropyranone; Michael addition; kinetics.; aerobic oxidation; acylation; N-heterocyclic carbene; green chemistry; Organocatalysis; electron transfer mediator; asymmetric synthesis;

    Sammanfattning : Oxidation reactions are ubiquitous in synthetic chemistry, but generally suffer from formation of large amounts of potentially toxic byproducts. Aerial oxygen represents an ideal oxidant since it is inexpensive, non-toxic and only forms water as a byproduct. LÄS MER

  5. 4. N-Heterocyclic Carbene Catalysis in Organic Synthesis - A Green Chemistry Approach

    Författare :Linda Ta; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; aerobic oxidation; ionic liquid; sustainability; NHC catalysis; oxidative NHC catalysis; green chemistry; OTHO; Organocatalysis;

    Sammanfattning : The twelve principles of green chemistry were created as a response to the multiple environmental issues caused by the release of waste from the chemical industry. The principles acts as a guide in the development of sustainable chemical processes for the syntheses of important molecules needed to sustain our living standards. LÄS MER

  7. 5. Late-stage 11C-carbonylation of drug-like molecules for PET

    Författare :Kaisa Horkka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Positron emission tomography (PET) is a non-invasive in vivo imaging technique used for translational biomedical research and clinical diagnosis. A fundamental pre-condition for PET is the radiolabelled tracer molecule used in the emission measurement, and there is a pressing need to accelerate the development of novel PET tracers to meet an increasing demand from the healthcare system, academia and drug industry. LÄS MER