Sökning: "oxazoles"
Hittade 3 avhandlingar innehållade ordet oxazoles.
1. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12
Sammanfattning : The glutamatergic mGlu5 receptor and the purinergic P2Y12 receptor are two important targets in the development of novel treatments of gastroesophageal reflux disease (GERD) and thrombosis, respectively. Synthesis was developed to investigate the structure-activity relationships (SAR) of a novel series of 2-alkynylpyridine derivatives as mGluR5 antagonists. LÄS MER
2. Transition-Metal Catalyzed Synthesis of Small- and Medium-Sized Rings Applications toward oxazole synthesis, cycloheptadienes, and natural products
Sammanfattning : This thesis deals with the development of novel methodologies for the synthesis of hetero- and carbocycles enabled by transition metal catalysis. The second chapter of the thesis describes a gold-catalyzed three-component reaction to form a variety of substituted oxazoles from readily available N-benzylimines, terminal alkynes, and acyl chlorides. LÄS MER
3. Rearrangements to vinyl substituted hetero- and carbocycles : Total synthesis of siphonazole B and otherapplications in oxazole and saturated ringsynthesis
Sammanfattning : The aim of this thesis is to explore and develop new reactions for rapid generation of molecular complexity. Byenabling access to important molecules in a less wasteful and more cost-efficient manner such developmentbenefits the whole modern society, where increasingly complex molecules are needed to solve problems withinfields ranging from medicine, to materials sciences and the perfume industry. LÄS MER
