Sökning: "ovarian neoplasm"

Hittade 5 avhandlingar innehållade orden ovarian neoplasm.

  1. 1. Hereditary breast and ovarian cancer in western Sweden with a special focus on BRCA1 3171ins5 mutation

    Författare :Zakaria Einbeigi; Göteborgs universitet; []
    Nyckelord :BRCA1 gene; breast neoplasm; ovarian neoplasm; hereditary; haplotype;

    Sammanfattning : Aims: To describe the phenotype and geographic distribution of the western Swedish founder mutation BRCA1 3171ins5, evaluate the reliability of mutation analysis of this mutation on archival material, analyse the haplotype for founder effects in families with BRCA1 3171ins5 mutation, estimate the age of this mutation and evaluate whether the occurrence of both breast and ovarian cancers in the same women may be a marker of a BRCA gene mutation. Materials and methods: The first study was based on 16 families with BRCA1 3171ins5 mutation and the second study was based on 18 families with the same mutation. LÄS MER

  3. 2. Ovarian tumors. Prevalence, malignancy risk and significance of the Plasminogen activation system

    Författare :Christer Borgfeldt; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproduktion; andrologi; gynekologi; sexuality; Obstetrik; Ovarian neoplasm; andrology; reproduction; epidemiology; ultrasonography; plasminogen activation; prognosis; gynaecology; Obstetrics; sexualitet;

    Sammanfattning : The aims were to assess the prevalence of ovarian tumors in fertile asymptomatic women and to evaluate the risk of ovarian cancer in women with a history of benign ovarian tumors and endometriosis. In order to search for biomarkers in ovarian tumors, the plasminogen activating (PA) system was studied. LÄS MER

  4. 3. Hereditary Breast Cancer in South Sweden. Early findings from studies on the role of BRCA1

    Författare :Oskar Thor Johannsson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; survival analysis; CGH; mRNA in situ hybridization; germline mutations; LOH; Breast neoplasm; BRCA1; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : The thesis presents the results from investigations into the role of BRCA1 in hereditary cancer in South Sweden. Loss of heterozygosity (LOH) studies found loss of the wildtype allele of BRCA1 to be common in BRCA1 associated breast cancer, but due to the high degree of LOH on chr. LÄS MER

  5. 4. Antibody Mediated Radionuclide Targeting of HER-2 for Cancer Diagnostics and Therapy : Preclinical Studies

    Författare :Mikael Persson; Per-Uno Malmström; Vladimir Tolmachev; Jörgen Carlsson; Marion De Jong; Uppsala universitet; []
    Nyckelord :Molecular medicine; Neoplasm Antibodies; Targeted Radiotherapy; Radionuclide Imaging; Molekylärmedicin;

    Sammanfattning : Targeted radionuclide therapy (TRT) holds great promise for the treatment of cancer. In TRT, radioactive nuclides are delivered specifically to tumours by molecules that recognise and bind to structures overexpressed by, or specific to, cancer cells. LÄS MER

  7. 5. Cancer and migration : epidemiological studies on relationship between country of birth, socio-economic position and cancer

    Författare :Omid Beiki; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Country of birth; immigrants; breast neoplasm; uterine cervical neoplasm; endometrial neoplasm; ovarian neoplasm; prostatic neoplasm; testicular neoplasm; socio-economic position; incidence; survival; Sweden;

    Sammanfattning : Background: Migrant studies offer a unique opportunity to analyze variation in disease occurrence due to background factors. The role of environmental and lifestyle exposures are of particular interest in cancer research, and migrant studies can be considered as "natural experiments" in epidemiological research. LÄS MER