Sökning: "ovarian failure"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden ovarian failure.

  1. 1. Clinical implementation of novel diagnostic biomarkers for epithelial ovarian cancer - Can we improve diagnosis?

    Författare :Maria Lycke; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ovarian neoplasms; EOC; Diagnosis; protein biomarkers; HE4; CA125; Algorithms; RMI; ROMA; NGS; rare mutations; liquid biopsies; screening;

    Sammanfattning : Background: Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer. The 5-year survival is about 30%, a consequence of failure to establish early diagnosis due to unspecific symptoms. LÄS MER

  3. 2. Molecular Characterisation of Structural Chromosomal Abnormalities Associated with Congenital Disorders

    Författare :Mahmoud R. Mansouri; Niklas Dahl; Hans Van Bokhoven; Uppsala universitet; []
    Nyckelord :Genetics; Chromosomal abnormalities; Mental retardation; Hypospadias and anal malformation; Premature ovarian failure; Autism; Array-CGH; ZDHHC15; Genetik;

    Sammanfattning : Chromosomal abnormalities are defined as changes in the chromosome structure and fall in one of two categories. The first category is numerical alterations while the second category consists of structural abnormalities. Structural chromosomal abnormalities do not always interrupt genes in order to cause disease. LÄS MER

  4. 3. Human ovarian follicle recruitment : an in vitro approach

    Författare :Jennifer E Scott; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Following the first reports of successful cryopreservation of human ovarian tissue, the freezing and banking of such tissue has become common practice worldwide for the preservation of fertility. Patients include those at risk of premature ovarian failure, women and girls with Turner's syndrome, and cancer patients for whom radiation or cytotoxic treatments are likely to destroy their reproductive potential. LÄS MER

  5. 4. Ovarian response to vascular and toxic insults in early life : focus on ovarian reserve and fertility preservation

    Författare :Valentina Pampanini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ovarian reserve is defined as the number of eggs embodied in primordial follicles. Every woman is born with a fixed number of primordial follicles, which are formed during fetal development. Pathological events can affect the ovarian reserve both preand postnatally and cause a premature ovarian insufficiency (POI), i.e. LÄS MER

  7. 5. Immunological recognition and tumor escape mechanisms of ovarian carcinoma

    Författare :Håkan Norell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor immunology; Immune escape; Antitumor immunity; Ovarian carcinoma; NK cells; HLA class 1; LOH; IFN-γ; CTL; HLA-G; HLA-E; Activating receptors; NK cell-based therapy;

    Sammanfattning : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. LÄS MER