Sökning: "osteosarcoma"

Visar resultat 16 - 20 av 34 avhandlingar innehållade ordet osteosarcoma.

  1. 16. Growth regulation in sarcomas : studies in vivo and in cell culture

    Författare :Avni Abdiu; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Sarcomas are malignant tumors of mesenchymal origin, and can arise in soft-tissue and in bones. It has been suggested that the abnormal growth regulation in sarcoma cells may be due to an autocrine mechanism, in which the cells are stimulated by an endogenous production of growth factors. LÄS MER

  3. 17. Model diseases for studies of autoimmunity

    Författare :Frida Dalin; Mohammad Alimohammadi; Olle Kämpe; Sophie Bensing; Lucia Mincheva-Nilsson; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : The events triggering autoimmune diseases are to large extent unknown and model diseases are an important tool in studies aiming to elucidate molecular mechanisms in autoimmunity. Autoimmune Addison’s disease (AAD) is a rare disease characterized by autoimmune destruction of adrenal glands and most patients with AAD have autoantibodies against the enzyme 21‑hydroxylase in the adrenal cortex. LÄS MER

  4. 18. Experimental studies on the effects of insulin-like growth factor I and glucocorticoids on bone metabolism

    Författare :Kenneth B. Jonsson; Uppsala universitet; []
    Nyckelord :Medical sciences; Bone; bone resorption; glucocorticoids; insulin-like growth factor I; osteoblasts; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Osteoporosis is a major cause of disability among patients that are dependent on glucocorticoids in the treatment of inflammatory disease. The pathogenesis behind this side effect is complex, involving dysregulation of hormonal systems and direct effects on bone cells. LÄS MER

  5. 19. Evaluation of genetic cancer predisposition and potential cancer genes

    Författare :Yaxuan Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Germline pathogenic TP53 variants are associated with a broad spectrum of hereditary cancers characterized from Li-Fraumeni syndrome (LFS) to hereditary breast cancer (HBC) outcomes, known as heritable TP53-related cancer (hTP53rc) syndrome. LFS is a rare inherited cancer syndrome characterized by premenopausal breast cancer, soft tissue sarcoma, brain tumor, osteosarcoma, and adrenocortical carcinoma. LÄS MER

  7. 20. Biocompatibility of synthetic nanomaterials and their applications in gene delivery

    Författare :Jingwen Shi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nanomedicine is the use of nanoscale or nanostructured materials in medicine that due to their structure have unique medical effects. Prominent applications of nanomedicine are the use of nanomaterials for the delivery of drugs and nucleic acids (to correct gene defects). LÄS MER