Sökning: "osteosarcoma"

Visar resultat 11 - 15 av 34 avhandlingar innehållade ordet osteosarcoma.

  1. 11. Vitamin D, bone turnover markers and hCAP-18 in children with hemato-oncological diseases

    Författare :Natalja Jackmann; Per Frisk; Outi Mäkitie; Jan Gustafsson; Anna Sällfors Holmqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vitamin D; pediatric cancer; leukemia; bone marrow failure; hCAP-18; bone turnover markers; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Children with hemato-oncological diseases may have significant skeletal morbidities. Vitamin D is essential for the maintenance of skeletal health and may also be important for immunological functions and cancer outcomes. LÄS MER

  3. 12. Vitamin A and Osteoporosis : Experimental and Clinical Studies

    Författare :Sara Johansson; Håkan Melhus; Andreas Kindmark; Monica Lind; Göran Toss; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Internal medicine; vitamin A; bone; osteoporosis; Invärtesmedicin; Internal medicine; Invärtesmedicin;

    Sammanfattning : Vitamin A in high doses is severely toxic to the rat skeleton, and the active metabolite retinoic acid (RA) can induce bone resorption in vitro. An excessive dietary intake of vitamin A has been associated with reduced bone mineral density and an increased risk of hip fracture. LÄS MER

  4. 13. The synergistic role of hierarchical macro- and mesoporous implant surface and microscopic view of enhanced osseointegration

    Författare :Guang Han; Zhijian Shen; Anders Palmqvist; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Porosity; cell adhesion; cell proliferation; surface topography; implant; bone-implant interface; argon ion beam polishing; osteogenesis; osseointegration; Materials Chemistry; materialkemi;

    Sammanfattning : The trend for designing of a titanium implant explored using different chemical compositions and crystallinity materials until people realized that the implant surface character was another important factor affecting the rate and extent of osseointegartion. Titanium received a macroporous titania surface layer by anodization, which contains open pores with average pore diameter around 5μm. LÄS MER

  5. 14. Identification, cloning and characterization of the p53 induced gene human Wig-1

    Författare :Fredrik Hellborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor suppressor p53 is a transcription factor that responds to various kinds of cellular stress. In respons to the sensed stress it is able to induces cell cycle arrest and apoptosis. In order to achieve these effects it transactivates target genes. LÄS MER

  7. 15. Vitamin D metabolism in osteoblast-like cells : effects of drugs on inactivation by CYP24A1

    Författare :Ahmad Zayny; Maria Norlin; Kjell Wikvall; Håkan Melhus; Inger Johansson; Fredrik Jerneren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical Biochemistry; Farmaceutisk biokemi; Pharmaceutical Biochemistry; Farmaceutisk biokemi;

    Sammanfattning : Vitamin D is essential for bone function, and deficiency in active vitamin D hormone can lead to bone disorders. Long-term treatment with glucocorticoids and antiretroviral drugs used to treat HIV infection, results in osteoporosis and increased risk of fractures. Much remains unclear regarding the effects of these compounds in bone cells. LÄS MER