Sökning: "osteomalacia"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet osteomalacia.

  1. 1. Vitamin D, muscle strength, prolonged labour, Caesarean sections and lifestyle : Clinical and intervention studies in pregnant Somali and Swedish women and new mothers

    Författare :Paul Kalliokoski; Monica Löfvander; Maria Bullarbo; Uppsala universitet; []
    Nyckelord :: caesarean section; dystocia; immigrant; muscle strength; obstetric labour complications; osteomalacia; physical performance; Somalia; vitamin D; vitamin D deficiency; Family Medicine; Allmänmedicin;

    Sammanfattning : Long-term severe vitamin D deficiency may cause osteomalacia with muscle weakness, pain, soft bones, cramps and eventually death. In a pilot study, I found many Somali women to be vitamin D deficient and very weak. LÄS MER

  3. 2. Dissertatio medica descriptionem et casus aliquot osteomalaciæ sistens, quam venia experientiss. Fac. Med. Upsal. præside Joh. Gust. Acrel, ... pro gradu doctoris, publico subjicit examini Olaus Jacobus Ekman, ... in audit. Gust. maj. d. X. Maji. MDCCLXXXVIII. Horis a. et p. meridiem solitis

    Författare :Johan Gustaf Acrel; Olof Jacob Ekman; Johan Gustaf Acrel; Uppsala universitet; []
    Nyckelord :Benvävnadsuppmjukning; Osteomalacia;

    Sammanfattning : .... LÄS MER

  4. 3. The Role of Fibroblast Growth Factor 23 in Phosphate Homeostasis

    Författare :Tobias Erik Martin Larsson; Kenneth Jonsson; Östen Ljunggren; Suzanne Jan De Beur; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Fibroblast Growth Factor 23; FGF-23; phosphate homeostasis; vitamin D metabolism; sodium phosphate cotransporters; autosomal dominant hypophosphatemic rickets; ADHR; X-linked hypophosphatemic rickets; XLH; oncogenic osteomalacia; OOM; PHEX; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : The regulation of serum phosphate (Pi) concentrations is a complex process and our current models are far from complete. Due to major advancements in biotechnology and the development of more powerful research tools, recent advances in the field of genetics has led to the identification of several candidates for the long sought-after phosphatonin(s), or Pi regulating hormones. LÄS MER

  5. 4. FGF23 - a possible Phosphatonin

    Författare :Richard Marsell; Kenneth Jonsson; Caroline Silve; Uppsala universitet; []
    Nyckelord :Surgery; Fibroblast growth factor 23; FGF23; FGF-23; Phosphate homeostasis; Vitamin D; Klotho; Parathyroid hormone; PTH; Kirurgi;

    Sammanfattning : Human physiology is dependent on an accurate phosphate (Pi) homeostasis. Defective Pi regulation causes hyper- or hypophosphatemia, which are associated with ectopic calcification or impaired bone mineralization, and a shortened life span. Current endocrine models of Pi homeostasis are incomplete. LÄS MER

  7. 5. Structural / functional studies on human alkaline phosphatases

    Författare :Alexey Kozlenkov; Jose-Luis Millan; Hans Jörnvall; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; mutagenesis; enzyme kinetics; computer modeling; crystallography; natural substrates; uncompetitive inhibition; isozymes; gene families; Biomedicin; Microbiology; Mikrobiologi; medicinsk genetik; Medical Genetics;

    Sammanfattning : The recent elucidation of the three-dimensional structure of human placental alkaline phosphatase (PLAP) has enabled me to perform structural studies aimed at characterizing the properties of human PLAP and tissue-nonspecific AP (TNAP) as paradigms for mammalian APs in general, using site-directed mutagenesis, protein expression, kinetic analysis and computer modeling. In Paper I, we found that a single critical E429G substitution explains the difference in stability and kinetics between the common allelic variants of PLAP and the D allozyme. LÄS MER