Sökning: "osteogenic differentiation"

Visar resultat 6 - 10 av 25 avhandlingar innehållade orden osteogenic differentiation.

  1. 6. Articular cartilage proteoglycan biosynthesis and sulfation

    Författare :Chengjuan Qu; Mikko Lammi; Heikki Helminen; Juha Töyräs; Anna-Marja Säämänen; Finland Kuopio University of Kuopio Anatomy Department of Biomedicine; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cartilage; Chondrocytes metabolism; Chondroitin sulfates; Glycosaminoglycans; Osteoarthritis; Proteoglycans; Glucosamine; Sulfation; Biochemistry; biokemi; cellforskning; cell research; Orthopaedics; ortopedi;

    Sammanfattning : Glucosamine (GlcN) and glucosamine sulfate (GS) have been used to treat the patients with osteoarthritis(OA) as a disease-modifying agent. Previousin vitro studies have focused on the effects of GlcN or GSon cartilage metabolism, whereas in vivo studies have investigated their potential for the treatment of OA. LÄS MER

  3. 7. Genetic modification and mesodermal differentiation of human embryonic stem cells

    Författare :Christian Unger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Pluripotent human embryonic stem cells (hESCs) are a resource of great potential, available for research. Their capability to differentiate into any cell of the human body and an unlimited in vitro expansion offers the possibility to study the earliest human development and provides a source of cells for regenerative medicine. LÄS MER

  4. 8. Regulating Gene Expression to Promote Osteoblastic Differentiation of Stem Cells

    Författare :Maruthibabu Paidikondala; Oommen P. Varghese; Jöns Hilborn; Laura Creemers; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Sammanfattning : Bone is a tissue that heals by itself, unless the defect is too large (critical size). Today, novel regenerative medicine approaches have emerged as an alternative to treat such defects. This thesis explores alternative therapeutic strategies for bone tissue engineering which are biocompatible and clinically translatable. LÄS MER

  5. 9. Multiscale Modelling of Proximal Femur Growth : Importance of Geometry and Influence of Load

    Författare :Priti Yadav; Elena Gutierrez Farewik; Marco Viceconti; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; bone tissue modeling; deformity; biomechanics; osteogenic index; poroelastic material; octahedral shear stress; hydrostatic stress; fluid velocity; octahedral shear strain; MRI; walking; jumping; sedentation; Engineering Mechanics; Teknisk mekanik;

    Sammanfattning : Longitudinal growth of long bone occurs at growth plates by a process called endochondral ossification. Endochondral ossification is affected by both biological and mechanical factors. LÄS MER

  7. 10. Development and optimization of a 3D in vitro model for osteogenic biomaterial evaluation

    Författare :Luis Oliveros Anerillas; Peyman Kelk; Paul J. Kingham; Mikko Lammi; Jöns Hilborn; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; angiogenesis; biomaterial; bone marrow mesenchymal stem cells; bone regeneration; hydrogel; osteoinduction; osteogenesis; scaffold; type I collagen; 3D culture; biology; biologi; biomedical laboratory science; biomedicinsk laboratorievetenskap; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Despite the innate regenerative capabilities of bone tissue, self-repair is impaired when an injury exceeds the critical size threshold because of trauma, congenital, or pathological conditions. Autologous transplantation is the gold standard to reconstruct large bone defects. LÄS MER