Sökning: "osteoclast"
Visar resultat 21 - 25 av 54 avhandlingar innehållade ordet osteoclast.
21. Aseptic Loosening of Orthopedic Implants : Osteoclastogenesis Regulation and Potential Therapeutics
Sammanfattning : Aseptic loosening is the main cause of failure of orthopedic prostheses. With no pharmaceuticals to prevent or mitigate periprosthetic bone degradation, a surgery to replace the loose implant with a new one is the only choice to restore patients’ function. LÄS MER
22. Pain in rheumatoid arthritis : bone and neuroinflammation-associated mechanisms
Sammanfattning : Pain is often the primary reason patients with rheumatoid arthritis (RA) seek medical care. Despite effective disease control with currently available disease modifying antirheumatic drugs (DMARDs), there are still hurdles to overcome as a significant proportion of patients still report continuous pain. LÄS MER
23. Vitamin A and Bone: Studies in vivo and in vitro
Sammanfattning : Background: Excess vitamin A is associated with decreased cortical bone and increased risk of fractures in humans. The aim of the present thesis was to assess the importance of vitamin A on the skeleton and bone cells in in vivo animal studies and mechanistic in vitro experiments. LÄS MER
24. The neuropeptide VIP and the IL-6 family of cytokines in bone : effects on bone resorption, cytokine expression and receptor signalling in osteoblasts and bone marrow stromal cells
Sammanfattning : Bone tissue is continuously degraded and rebuilt to respond to the needs of the body. Cells of the osteoblast lineage are responsible for the formation of bone, whereas the resorption of bone tissue is carried out by osteoclasts. LÄS MER
25. Functions of estrogen receptor b in the metabolism of rodent bone
Sammanfattning : Estrogens are important for widespread biological functions including regulation of development and maintenance of skeletal tissue. The effects of estrogens are thought to be mediated via two intracellular proteins, estrogen receptors a and beta (ERalpha and ERbeta , respectively), which are expressed in most cell types in bone. LÄS MER